TY - JOUR
T1 - Epstein-Barr virus types 1 and 2 have nearly identical LMP-1 transforming genes
AU - Sample, J.
AU - Kieff, E. F.
AU - Kieff, E. D.
PY - 1994
Y1 - 1994
N2 - Although variation in the gene encoding the Epstein-Barr virus (EBV) nuclear protein 2 accounts for much of the difference in the transforming activities of the two EBV strain types, divergence in the principal lymphocyte growth-altering gene, LMP-1, has not been previously evaluated. We have now determined the nucleotide sequence of the LMP-1 gene of a type 2 isolate of EBV, AG876. Surprisingly, the AG876 LMP-1 protein is 93% identical to the prototype type 1 EBV strain B95-8, and this is well within the range of variability previously noted among type 1 EBV LMP-1 genes.
AB - Although variation in the gene encoding the Epstein-Barr virus (EBV) nuclear protein 2 accounts for much of the difference in the transforming activities of the two EBV strain types, divergence in the principal lymphocyte growth-altering gene, LMP-1, has not been previously evaluated. We have now determined the nucleotide sequence of the LMP-1 gene of a type 2 isolate of EBV, AG876. Surprisingly, the AG876 LMP-1 protein is 93% identical to the prototype type 1 EBV strain B95-8, and this is well within the range of variability previously noted among type 1 EBV LMP-1 genes.
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U2 - 10.1099/0022-1317-75-10-2741
DO - 10.1099/0022-1317-75-10-2741
M3 - Article
C2 - 7931160
AN - SCOPUS:0028085706
SN - 0022-1317
VL - 75
SP - 2741
EP - 2746
JO - Journal of General Virology
JF - Journal of General Virology
IS - 10
ER -