Erythrosine (red no. 3) and its nonspecific biochemical actions: What relation to behavioral changes?

Richard B. Mailman; Robert M. Ferris; Flora L.M. Tang; Richard A. Vogel; Clinton D. Kilts; Morris A. Lipton; Dorothy A. Smith; Robert A. Mueller; George R. Breese

doi:10.1126/science.7352264

Erythrosine (red no. 3) and its nonspecific biochemical actions: What relation to behavioral changes?

Richard B. Mailman, Robert M. Ferris, Flora L.M. Tang, Richard A. Vogel, Clinton D. Kilts, Morris A. Lipton, Dorothy A. Smith, Robert A. Mueller, George R. Breese

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Abstract

Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control or 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.

Original language	English (US)
Pages (from-to)	535-537
Number of pages	3
Journal	Science
Volume	207
Issue number	4430
DOIs	https://doi.org/10.1126/science.7352264
State	Published - 1980

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title = "Erythrosine (red no. 3) and its nonspecific biochemical actions: What relation to behavioral changes?",

abstract = "Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control or 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a {"}conflict{"} paradigm.",

author = "Mailman, {Richard B.} and Ferris, {Robert M.} and Tang, {Flora L.M.} and Vogel, {Richard A.} and Kilts, {Clinton D.} and Lipton, {Morris A.} and Smith, {Dorothy A.} and Mueller, {Robert A.} and Breese, {George R.}",

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T1 - Erythrosine (red no. 3) and its nonspecific biochemical actions

T2 - What relation to behavioral changes?

AU - Mailman, Richard B.

AU - Ferris, Robert M.

AU - Tang, Flora L.M.

AU - Vogel, Richard A.

AU - Kilts, Clinton D.

AU - Lipton, Morris A.

AU - Smith, Dorothy A.

AU - Mueller, Robert A.

AU - Breese, George R.

PY - 1980

Y1 - 1980

N2 - Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control or 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.

AB - Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control or 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.

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Erythrosine (red no. 3) and its nonspecific biochemical actions: What relation to behavioral changes?

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