Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia

Larisa Suturina, Daria Lizneva, Alina Atalyan, Ludmila Lazareva, Aleksey Belskikh, Tatyana Bairova, Leonid Sholokhov, Maria Rashidova, Irina Danusevich, Iana Nadeliaeva, Lilia Belenkaya, Zorikto Darzhaev, Eldar Sharifulin, Natalia Belkova, Ilia Igumnov, Tatyana Trofimova, Anastasiya Khomyakova, Kseniia Ievleva, Natalia Babaeva, Irina EgorovaMadinabonu Salimova, Bulent O. Yildiz, Richard S. Legro, Frank Z. Stanczyk, Ricardo Azziz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Androgen assessment is a key element for diagnosing polycystic ovary syndrome (PCOS), and defining a “normal” level of circulating androgens is critical for epidemiological studies. We determined the upper normal limits (UNLs) for androgens in a population-based group of premenopausal “healthy control” women, overall and by ethnicity (Caucasian and Asian), in the cross-sectional Eastern Siberia PCOS Epidemiology and Phenotype (ESPEP) Study (ClinicalTrials.gov ID: NCT05194384) conducted in 2016–2019. Overall, we identified a “healthy control” group consisting of 143 healthy premenopausal women without menstrual dysfunction, hirsutism, polycystic ovaries, or medical disorders. We analyzed serum total testosterone (TT) by using liquid chromatography with tandem mass spectrometry (LC-MS/MS), and DHEAS, sex-hormone-binding globulin (SHBG), TSH, prolactin, and 17-hydroxyprogesterone (17OHP) were assessed with an enzyme-linked immunosorbent assay (ELISA). The UNLs for the entire population for the TT, free androgen index (FAI), and DHEAS were determined as the 98th percentiles in healthy controls as follows: 67.3 (95% confidence interval (CI): 48.1, 76.5) ng/dl, 5.4 (3.5, 14.0), and 355 (289, 371) μg/dl, respectively. The study results demonstrated that the UNLs for TT and FAI varied by ethnicity, whereas the DHEAS UNLs were comparable in the ethnicities studied.

Original languageEnglish (US)
Article number33
JournalDiagnostics
Volume13
Issue number1
DOIs
StatePublished - Jan 2023

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Fingerprint

Dive into the research topics of 'Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia'. Together they form a unique fingerprint.

Cite this