TY - JOUR
T1 - Establishment and characterization of a new endometrial cancer cell line (SCRC-1)
AU - Gorodecki, J.
AU - Mortel, R.
AU - Ladda, R. L.
AU - Ward, S. P.
AU - Geder, L.
AU - Rapp, F.
PY - 1979
Y1 - 1979
N2 - A new human endometrial cell line, SCRC-1, has been established from a uterine adenocarcinoma. During a period of 57 wk in culture, the SCRC-1 cells have been passaged over 100 times. Cultures have an epithelioid morphology, high mitotic activity, and a tendency to form multiple cell layers. The cells are polygonal and are arranged in pavement-like fashion. Most have multiple nucleoli, some are multinucleated, and all have heavily vacuolated cytoplasm. Pretreatment with iododeoxyuridine did not reveal viral markers by cocultivation or immunofluorescence techniques. Karyologic studies indicate that the SCRC-1 cell line is essentially diploid with a small subpopulation of tetraploid cells. Over a period of 20 wk, 1 of 14 athymic nude mice inoculated with SCRC-1 cells developed a tumor which histologically closely resembled the original human tumor. Cells were subsequently propagated from this tumor and the resulting epithelioid-like cell line was designated SCRC-1, Tu 1.
AB - A new human endometrial cell line, SCRC-1, has been established from a uterine adenocarcinoma. During a period of 57 wk in culture, the SCRC-1 cells have been passaged over 100 times. Cultures have an epithelioid morphology, high mitotic activity, and a tendency to form multiple cell layers. The cells are polygonal and are arranged in pavement-like fashion. Most have multiple nucleoli, some are multinucleated, and all have heavily vacuolated cytoplasm. Pretreatment with iododeoxyuridine did not reveal viral markers by cocultivation or immunofluorescence techniques. Karyologic studies indicate that the SCRC-1 cell line is essentially diploid with a small subpopulation of tetraploid cells. Over a period of 20 wk, 1 of 14 athymic nude mice inoculated with SCRC-1 cells developed a tumor which histologically closely resembled the original human tumor. Cells were subsequently propagated from this tumor and the resulting epithelioid-like cell line was designated SCRC-1, Tu 1.
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U2 - 10.1016/S0002-9378(16)32994-5
DO - 10.1016/S0002-9378(16)32994-5
M3 - Article
C2 - 228555
AN - SCOPUS:0018697340
SN - 0002-9378
VL - 135
SP - 671
EP - 679
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 5
ER -