TY - JOUR
T1 - Esterification as a Demonstration of Electrochemically Powered Catalytic Dehydration
AU - Haines, Christopher A.
AU - Han, Jian
AU - Nacsa, Eric D.
N1 - Publisher Copyright:
© 2023 Georg Thieme Verlag. All rights reserved.
PY - 2023
Y1 - 2023
N2 - The reliance on wasteful stoichiometric reagents to accomplish dehydration reactions such as esterification, amidation, and alcohol substitution is a longstanding challenge in synthetic chemistry. To address this problem, an electrochemical approach has been developed as a new conceptual platform for dehydration reactions. As a proof-ofconcept demonstration, an electrochemical esterification protocol has been described that proceeds at room temperature, without acid or base additives, and without consuming stoichiometric reagents. This approach therefore overcomes key complications of esterification chemistry, and we envision that it will similarly enable improvements to a range of important, related transformations. 1 Introduction 2 An Electrochemical Design for Catalytic Dehydration 3 Electrochemical Esterification 4 Conclusions.
AB - The reliance on wasteful stoichiometric reagents to accomplish dehydration reactions such as esterification, amidation, and alcohol substitution is a longstanding challenge in synthetic chemistry. To address this problem, an electrochemical approach has been developed as a new conceptual platform for dehydration reactions. As a proof-ofconcept demonstration, an electrochemical esterification protocol has been described that proceeds at room temperature, without acid or base additives, and without consuming stoichiometric reagents. This approach therefore overcomes key complications of esterification chemistry, and we envision that it will similarly enable improvements to a range of important, related transformations. 1 Introduction 2 An Electrochemical Design for Catalytic Dehydration 3 Electrochemical Esterification 4 Conclusions.
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U2 - 10.1055/s-0042-1751543
DO - 10.1055/s-0042-1751543
M3 - Article
AN - SCOPUS:85182682171
SN - 0936-5214
JO - Synlett
JF - Synlett
ER -