TY - JOUR
T1 - Estimating rates of multiple gestation pregnancies
T2 - Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial
AU - Diamond, Michael P.
AU - Mitwally, Mohamed
AU - Casper, Robert
AU - Ager, Joel
AU - Legro, Richard S.
AU - Brzyski, Robert
AU - Casson, Peter
AU - Eisenberg, Esther
AU - Zhang, Heping
N1 - Funding Information:
Supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( 5U10 HD 039005 , 3U10 HD 039005-S1 , 5U10 HD 038992 , 3U10 HD 038992-S1 , 5U10 HD 055942 , 3U10 HD 055942-S1 , 5U10 HD 055944 , 3U10 HD 055944-S1 , 5U10HD055925 , 5U10HD055925-S1 ).
PY - 2011/11
Y1 - 2011/11
N2 - Infertility afflicts 15% of couples who wish to conceive. Despite intensive evaluation of both male and female partners, the etiology may remain unknown leading to a diagnosis of unexplained infertility. For such couples, treatment often entails ovulation induction (OI) with fertility medications coupled with intrauterine insemination. Complications of this therapy include ovarian hyperstimulation syndrome and creation of multiple gestation pregnancies, which can be complicated by preterm labor and delivery, and the associated neonatal morbidity and expense of care for preterm infants. The Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) study is designed to assess whether OI in couples with unexplained infertility with an aromatase inhibitor produces mono-follicular development in most cycles, thereby reducing multiple gestations while maintaining a comparable pregnancy success rate to that achieved by OI with either gonadotropins or clomiphene citrate. These results will provide future guidance of therapy for couples with unexplained infertility, and if comparable pregnancy rates are achieved with a substantial reduction in multiple gestations, the public health benefit will be considerable.
AB - Infertility afflicts 15% of couples who wish to conceive. Despite intensive evaluation of both male and female partners, the etiology may remain unknown leading to a diagnosis of unexplained infertility. For such couples, treatment often entails ovulation induction (OI) with fertility medications coupled with intrauterine insemination. Complications of this therapy include ovarian hyperstimulation syndrome and creation of multiple gestation pregnancies, which can be complicated by preterm labor and delivery, and the associated neonatal morbidity and expense of care for preterm infants. The Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) study is designed to assess whether OI in couples with unexplained infertility with an aromatase inhibitor produces mono-follicular development in most cycles, thereby reducing multiple gestations while maintaining a comparable pregnancy success rate to that achieved by OI with either gonadotropins or clomiphene citrate. These results will provide future guidance of therapy for couples with unexplained infertility, and if comparable pregnancy rates are achieved with a substantial reduction in multiple gestations, the public health benefit will be considerable.
UR - http://www.scopus.com/inward/record.url?scp=80053383258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053383258&partnerID=8YFLogxK
U2 - 10.1016/j.cct.2011.07.009
DO - 10.1016/j.cct.2011.07.009
M3 - Article
C2 - 21787883
AN - SCOPUS:80053383258
SN - 1551-7144
VL - 32
SP - 902
EP - 908
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
IS - 6
ER -