Estimating the acute effects of fine and coarse particle pollution on stroke mortality of in six Chinese subtropical cities

Xiaojie Wang, Zhengmin Qian, Xiaojie Wang, Hua Hong, Yin Yang, Yanjun Xu, Xiaojun Xu, Zhenjiang Yao, Lingli Zhang, Craig A. Rolling, Mario Schootman, Tao Liu, Jianpeng Xiao, Xing Li, Weilin Zeng, Wenjun Ma, Hualiang Lin

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


While increasing evidence suggested that PM2.5 is the most harmful fraction of the particle pollutants, the health effects of coarse particles (PM10-2.5) have been inconclusive, especially on cerebrovascular diseases, we thus evaluated the effects of PM10, PM2.5, and PM10-2.5 on stroke mortality in six Chinese subtropical cities using generalized additive models. We also conducted random-effects meta-analyses to estimate the overall effects across the six cities. We found that PM10, PM2.5, and PM10-2.5 were significantly associated with stroke mortality. Each 10 μg/m3 increase of PM10, PM2.5 and PM10-2.5 (lag03) was associated with an increase of 1.88% (95% CI: 1.37%, 2.39%), 3.07% (95% CI: 2.35%, 3.79%), and 5.72% (95% CI: 3.82%, 7.65%) in overall stroke mortality. Using the World Health Organization's guideline as reference concentration, we estimated that 3.21% (95% CI: 1.65%, 3.01%) of stroke mortality (corresponding to 1743 stroke mortalities, 95% CI: 896, 1633) were attributed to PM10, 5.57% (95% CI: 0.50%, 1.23%) stroke mortality (3019, 95% CI: 2286, 3777) were attributed to PM2.5, and 2.02% (95% CI: 1.85%, 3.08%) of stroke mortality (1097, 95% CI: 1005, 1673) could be attributed to PM10-2.5. Our analysis indicates that both PM2.5 and PM10-2.5 are important risk factors of stroke mortality and should be considered in the prevention and control of stroke in the study area.

Original languageEnglish (US)
Pages (from-to)812-817
Number of pages6
JournalEnvironmental Pollution
StatePublished - Aug 2018

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis


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