Abstract
Oral direct-acting antiviral agents have revolutionized treatment of hepatitis C virus (HCV) infection. Nonetheless, barriers exist to elimination of HCV as a public health threat including low uptake of treatment, limited budget allocations for HCV treatment, and low awareness rates of HCV status among infected people. Mathematical modeling provides a systematic framework to analyze and compare potential solutions and elimination strategies by simulating the HCV epidemic under different conditions. Such models evaluate impact of interventions in advance of implementation. This article describes key components of developing an HCV burden model and illustrates its use by simulating the HCV epidemic in the United States.
Original language | English (US) |
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Pages (from-to) | 461-480 |
Number of pages | 20 |
Journal | Infectious Disease Clinics of North America |
Volume | 32 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2018 |
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases