Abstract
Recent experimental studies suggest a role for estrogens in chondrocyte metabolism and the development and treatment of osteoarthritis. Type I cytoplasmic estradiol receptors were found in articular chondrocytes. The presence of these receptors supports a possible mechanism for previous observations on estrogen suppressive effects on cartilage proteoglycan synthesis and offers a basis for further study on the role of estrogens in the physiology of cartilage and in the pathogenesis and treatment of osteoarthritis.
Original language | English (US) |
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Pages (from-to) | 1378-1382 |
Number of pages | 5 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 106 |
Issue number | 4 |
DOIs | |
State | Published - Jun 30 1982 |
All Science Journal Classification (ASJC) codes
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology