Estradiol receptors in articular chondrocytes

Itzhak A. Rosner; Andrea Manni; Charles J. Malemud; Beata Boja; Roland W. Moskowitz

doi:10.1016/0006-291X(82)91266-9

Estradiol receptors in articular chondrocytes

Itzhak A. Rosner
, Andrea Manni
, Charles J. Malemud
, Beata Boja
, Roland W. Moskowitz

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Recent experimental studies suggest a role for estrogens in chondrocyte metabolism and the development and treatment of osteoarthritis. Type I cytoplasmic estradiol receptors were found in articular chondrocytes. The presence of these receptors supports a possible mechanism for previous observations on estrogen suppressive effects on cartilage proteoglycan synthesis and offers a basis for further study on the role of estrogens in the physiology of cartilage and in the pathogenesis and treatment of osteoarthritis.

Original language	English (US)
Pages (from-to)	1378-1382
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	106
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(82)91266-9
State	Published - Jun 30 1982

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(82)91266-9

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title = "Estradiol receptors in articular chondrocytes",

abstract = "Recent experimental studies suggest a role for estrogens in chondrocyte metabolism and the development and treatment of osteoarthritis. Type I cytoplasmic estradiol receptors were found in articular chondrocytes. The presence of these receptors supports a possible mechanism for previous observations on estrogen suppressive effects on cartilage proteoglycan synthesis and offers a basis for further study on the role of estrogens in the physiology of cartilage and in the pathogenesis and treatment of osteoarthritis.",

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AU - Rosner, Itzhak A.

AU - Manni, Andrea

AU - Malemud, Charles J.

AU - Boja, Beata

AU - Moskowitz, Roland W.

PY - 1982/6/30

Y1 - 1982/6/30

N2 - Recent experimental studies suggest a role for estrogens in chondrocyte metabolism and the development and treatment of osteoarthritis. Type I cytoplasmic estradiol receptors were found in articular chondrocytes. The presence of these receptors supports a possible mechanism for previous observations on estrogen suppressive effects on cartilage proteoglycan synthesis and offers a basis for further study on the role of estrogens in the physiology of cartilage and in the pathogenesis and treatment of osteoarthritis.

AB - Recent experimental studies suggest a role for estrogens in chondrocyte metabolism and the development and treatment of osteoarthritis. Type I cytoplasmic estradiol receptors were found in articular chondrocytes. The presence of these receptors supports a possible mechanism for previous observations on estrogen suppressive effects on cartilage proteoglycan synthesis and offers a basis for further study on the role of estrogens in the physiology of cartilage and in the pathogenesis and treatment of osteoarthritis.

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U2 - 10.1016/0006-291X(82)91266-9

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M3 - Article

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AN - SCOPUS:0020446694

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Estradiol receptors in articular chondrocytes

Abstract

All Science Journal Classification (ASJC) codes

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