Estrogen therapy and variable‐resistance weight training increase bone mineral in surgically menopausal women

Morris Notelovitz, Daniel Martin, Rogene Tesar, Farouk Y. Khan, Claudia Probart, Carol Fields, Lynda McKenzie

Research output: Contribution to journalArticlepeer-review

180 Scopus citations


This study was undertaken to examine the effect of estrogen replacement therapy alone and estrogen replacement therapy plus variable‐resistance weight training on the bone mineral content of surgically menopausal women. A total of 20 surgically menopausal women were randomized and treated with either 0.625 mg conjugated estrogen daily or the same dose of estrogen plus a closely monitored exercise program involving the use of Nautilus muscle strengthening/endurance equipment. After 1 year's observation, the bone mineral density (BMD) of the spine determined by dual‐photon absorptiometry increased in the exercising subjects by 8.3 ± 5.3% (p = 0.004), 95% confidence limits (CL) 3.9–12.8%; the group with estrogen replacement therapy alone maintained their BMD: 1.5 ± 12.4% (p = 0.36; 95% CL = −6.9–9.8%). The total body BMD of the exercising group increased by 2.1 ± 1.5% (p = 0.003; 95% CL = 0.8–3.3%); the nonexercising women had a nonsignificant 0.6 ± 2.9% change (p = 0.30; 95% CL = −1.4–2.5%). A significant increase of 4.1 ± 4.3% (p = 0.01; 95% CL = 0.8–7.4%) in the radial midshaft BMD of the exercising group was found; the estrogen alone group recorded a nonsignificant change of −0.3 ± 3.1% (p = 0.33; 95% CL = −1.7–2.4%). The results of this study suggest that variable‐resistance training in estrogen‐replete women adds bone to both the axial and appendicular skeleton.

Original languageEnglish (US)
Pages (from-to)583-590
Number of pages8
JournalJournal of Bone and Mineral Research
Issue number6
StatePublished - Jun 1991

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


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