Ethanol: An Enhancer of Transplantation Antigen Expression

Dinah S. Singer; Leslie J. Parent; Michael A. Kolber

doi:10.1111/j.1530-0277.1989.tb00360.x

Ethanol: An Enhancer of Transplantation Antigen Expression

Dinah S. Singer, Leslie J. Parent, Michael A. Kolber

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18 Scopus citations

Abstract

Major histocompatibility antigens (MHC) play a pivotal role in the immune response. Abnormal expression of MHC antigens has been correlated with aberrant regulation of the immune response. Studies on the effect of ethanol on class I MHC antigens demonstrate that ethanol significantly enhances their cell surface expression in a variety of cell lines in vitro. These changes in cell surface levels reflect increased intracellular protein synthesis and increased steady state mRNA levels. The effective ethanol concentrations (0.1‐1.0%) are physiologically attainable. Measurement of class I MHC antigens on peripheral blood lymphocytes in a population of acutely ethanol‐intoxicated patients showed a highly significant increase relative to controls. The possibility that the elevated levels of MHC antigens induced by ethanol may play a role in the evolution of ethanol‐related disease is discussed.

Original language	English (US)
Pages (from-to)	480-484
Number of pages	5
Journal	Alcoholism: Clinical and Experimental Research
Volume	13
Issue number	4
DOIs	https://doi.org/10.1111/j.1530-0277.1989.tb00360.x
State	Published - Aug 1989

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Toxicology
Psychiatry and Mental health

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10.1111/j.1530-0277.1989.tb00360.x

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title = "Ethanol: An Enhancer of Transplantation Antigen Expression",

abstract = "Major histocompatibility antigens (MHC) play a pivotal role in the immune response. Abnormal expression of MHC antigens has been correlated with aberrant regulation of the immune response. Studies on the effect of ethanol on class I MHC antigens demonstrate that ethanol significantly enhances their cell surface expression in a variety of cell lines in vitro. These changes in cell surface levels reflect increased intracellular protein synthesis and increased steady state mRNA levels. The effective ethanol concentrations (0.1‐1.0%) are physiologically attainable. Measurement of class I MHC antigens on peripheral blood lymphocytes in a population of acutely ethanol‐intoxicated patients showed a highly significant increase relative to controls. The possibility that the elevated levels of MHC antigens induced by ethanol may play a role in the evolution of ethanol‐related disease is discussed.",

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T2 - An Enhancer of Transplantation Antigen Expression

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AU - Parent, Leslie J.

AU - Kolber, Michael A.

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AB - Major histocompatibility antigens (MHC) play a pivotal role in the immune response. Abnormal expression of MHC antigens has been correlated with aberrant regulation of the immune response. Studies on the effect of ethanol on class I MHC antigens demonstrate that ethanol significantly enhances their cell surface expression in a variety of cell lines in vitro. These changes in cell surface levels reflect increased intracellular protein synthesis and increased steady state mRNA levels. The effective ethanol concentrations (0.1‐1.0%) are physiologically attainable. Measurement of class I MHC antigens on peripheral blood lymphocytes in a population of acutely ethanol‐intoxicated patients showed a highly significant increase relative to controls. The possibility that the elevated levels of MHC antigens induced by ethanol may play a role in the evolution of ethanol‐related disease is discussed.

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Ethanol: An Enhancer of Transplantation Antigen Expression

Abstract

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