TY - JOUR
T1 - Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians
AU - Chen, Dingyan
AU - Liu, Li
AU - Xiao, Yang
AU - Peng, Yuehua
AU - Yang, Chengwu
AU - Wang, Zengzhen
N1 - Funding Information:
This study was partly supported by the National Natural Science Foundation of China (No. 30872175 ). The funding source had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Background: Many studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results were inconsistent. To better understand this relationship, ethnicity-specific meta-analyses were conducted. Methods: We retrieved all eligible studies published up to April 12, 2011 from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases. Ethnicity-specific meta-analyses were performed using either fixed- or random-effect models as appropriate. Results: Twelve independent studies with 1900 cases and 2382 controls were included. Five studies were conducted in Asians and seven in Caucasians. Ethnicity-specific meta-analyses revealed that the A118G polymorphism was significantly associated with alcohol dependence risk in Asians (GA vs. AA: odds ratio [OR], 1.73; 95% confidence interval [CI], 1.33-2.25; GA + GG vs. AA: OR, 1.57; 95% CI, 1.22-2.02), but not in Caucasians (GA vs. AA: OR, 1.05; 95% CI, 0.75-1.49; GA + GG vs. AA: OR, 1.11; 95% CI, 0.79-1.55). Conclusions: The OPRM1 A118G polymorphism may contribute to the susceptibility of alcohol dependence in Asians but not in Caucasians.
AB - Background: Many studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results were inconsistent. To better understand this relationship, ethnicity-specific meta-analyses were conducted. Methods: We retrieved all eligible studies published up to April 12, 2011 from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases. Ethnicity-specific meta-analyses were performed using either fixed- or random-effect models as appropriate. Results: Twelve independent studies with 1900 cases and 2382 controls were included. Five studies were conducted in Asians and seven in Caucasians. Ethnicity-specific meta-analyses revealed that the A118G polymorphism was significantly associated with alcohol dependence risk in Asians (GA vs. AA: odds ratio [OR], 1.73; 95% confidence interval [CI], 1.33-2.25; GA + GG vs. AA: OR, 1.57; 95% CI, 1.22-2.02), but not in Caucasians (GA vs. AA: OR, 1.05; 95% CI, 0.75-1.49; GA + GG vs. AA: OR, 1.11; 95% CI, 0.79-1.55). Conclusions: The OPRM1 A118G polymorphism may contribute to the susceptibility of alcohol dependence in Asians but not in Caucasians.
UR - http://www.scopus.com/inward/record.url?scp=84861223580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861223580&partnerID=8YFLogxK
U2 - 10.1016/j.drugalcdep.2011.10.012
DO - 10.1016/j.drugalcdep.2011.10.012
M3 - Review article
C2 - 22071118
AN - SCOPUS:84861223580
SN - 0376-8716
VL - 123
SP - 1
EP - 6
JO - Drug and alcohol dependence
JF - Drug and alcohol dependence
IS - 1-3
ER -
