TY - JOUR
T1 - Etiologic Evaluation of Male Pseudohermaphroditism in Infancy and Childhood
AU - Berkovitz, Gary D.
AU - Lee, Peter
AU - Brown, Terry R.
AU - Migeon, Claude J.
PY - 1984/8
Y1 - 1984/8
N2 - We outlined a diagnostic scheme for use with prepubertal patients with male pseudohermaphroditism that included karyotyping, a genitourethrogram, a human chorionic gonadotropin stimulation test with plasma hormone level determinations, and determination of 5α-reductase activity and androgen receptor binding in genital skin fibroblasts. A thorough evaluation is warranted in all patients since the correct diagnosis may assist in determining gender assignment and providing appropriate genetic counseling. We studied 25 patients by the prescribed diagnostic scheme: seven of them had a partial gonadal dysgenesis, two were deficient in 5α-reductase activity, two showed partial androgen insensitivity, four had multiple congenital malformations, one had a Wilms' tumor, and nine were considered as having an idiopathic form of MPH.
AB - We outlined a diagnostic scheme for use with prepubertal patients with male pseudohermaphroditism that included karyotyping, a genitourethrogram, a human chorionic gonadotropin stimulation test with plasma hormone level determinations, and determination of 5α-reductase activity and androgen receptor binding in genital skin fibroblasts. A thorough evaluation is warranted in all patients since the correct diagnosis may assist in determining gender assignment and providing appropriate genetic counseling. We studied 25 patients by the prescribed diagnostic scheme: seven of them had a partial gonadal dysgenesis, two were deficient in 5α-reductase activity, two showed partial androgen insensitivity, four had multiple congenital malformations, one had a Wilms' tumor, and nine were considered as having an idiopathic form of MPH.
UR - http://www.scopus.com/inward/record.url?scp=0021263018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021263018&partnerID=8YFLogxK
U2 - 10.1001/archpedi.1984.02140460047017
DO - 10.1001/archpedi.1984.02140460047017
M3 - Article
C2 - 6331153
AN - SCOPUS:0021263018
SN - 0096-8994
VL - 138
SP - 755
EP - 759
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 8
ER -