Eukaryotic transcription factors

Song Tan; Timothy J. Richmond

doi:10.1016/S0959-440X(98)80008-0

Eukaryotic transcription factors

Song Tan, Timothy J. Richmond

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The structural characterization of eukaryotic transcription factors that interact with DNA has advanced on two fronts in the past two years. New complexes of transcription factors bound to TATA-box DNA include the TFIIA-TBP-DNA complex as well as human and archaeal TBP-DNA and TFIIB-TBP-DNA complexes, respectively. In addition, recent studies of proximal/distal promoter complexes demonstrate that DNA-binding motifs may be modified in nature by adding secondary structure elements to diversify DNA-binding specificities and affinities.

Original language	English (US)
Pages (from-to)	41-48
Number of pages	8
Journal	Current Opinion in Structural Biology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/S0959-440X(98)80008-0
State	Published - Feb 1998

All Science Journal Classification (ASJC) codes

Structural Biology
Molecular Biology

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10.1016/S0959-440X(98)80008-0

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abstract = "The structural characterization of eukaryotic transcription factors that interact with DNA has advanced on two fronts in the past two years. New complexes of transcription factors bound to TATA-box DNA include the TFIIA-TBP-DNA complex as well as human and archaeal TBP-DNA and TFIIB-TBP-DNA complexes, respectively. In addition, recent studies of proximal/distal promoter complexes demonstrate that DNA-binding motifs may be modified in nature by adding secondary structure elements to diversify DNA-binding specificities and affinities.",

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AB - The structural characterization of eukaryotic transcription factors that interact with DNA has advanced on two fronts in the past two years. New complexes of transcription factors bound to TATA-box DNA include the TFIIA-TBP-DNA complex as well as human and archaeal TBP-DNA and TFIIB-TBP-DNA complexes, respectively. In addition, recent studies of proximal/distal promoter complexes demonstrate that DNA-binding motifs may be modified in nature by adding secondary structure elements to diversify DNA-binding specificities and affinities.

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Eukaryotic transcription factors

Abstract

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