Eukaryotic transcription factors

Song Tan, Timothy J. Richmond

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


The structural characterization of eukaryotic transcription factors that interact with DNA has advanced on two fronts in the past two years. New complexes of transcription factors bound to TATA-box DNA include the TFIIA-TBP-DNA complex as well as human and archaeal TBP-DNA and TFIIB-TBP-DNA complexes, respectively. In addition, recent studies of proximal/distal promoter complexes demonstrate that DNA-binding motifs may be modified in nature by adding secondary structure elements to diversify DNA-binding specificities and affinities.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalCurrent Opinion in Structural Biology
Issue number1
StatePublished - Feb 1998

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology


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