TY - JOUR
T1 - Evaluating smoking cessation interventions for people living with HIV in a factorial randomised clinical trial in South Africa using the Multiphase Optimization Strategy (MOST) framework
T2 - The Tlogela Trial protocol
AU - Genade, Leisha P.
AU - Steiner, Laura
AU - Nabeemeeah, Firdaus
AU - Niaura, Raymond S.
AU - Nonyane, Bareng A.S.
AU - Hoffmann, Christopher J.
AU - Sohn, Hojoon
AU - Kemp, Christopher G.
AU - Guastaferro, Kate
AU - Mlambo, Lebohang
AU - Chetty, Deshan
AU - Waja, Ziyaad
AU - Martinson, Neil
AU - Golub, Jonathan E.
AU - Elf, Jessica L.
N1 - Publisher Copyright:
© 2024
PY - 2025/8
Y1 - 2025/8
N2 - Background: Human immunodeficiency virus (HIV) remains an important cause of morbidity and mortality in South Africa (SA) with a gradual shift from opportunistic illness to pulmonary and cardiovascular disease among people living with HIV (PLWH). This shift is exacerbated by increases in prevalence of tobacco smoking and also few resources to support smoking cessation. Evidence-based smoking cessation strategies are yet to be fully evaluated among PLWH in this setting. Objective: This project will optimize a smoking cessation treatment package for PLWH that can be integrated into existing HIV care in SA. We will identify the most effective and/or combination of the interventions and evaluate their potential for implementation and cost-effectiveness. Methods: A balanced 24 full factorial clinical trial will randomise 660 PLWH who smoke tobacco into one of 16 combinations of four intervention components (behavioural counselling, peer counselling, varenicline, and combination nicotine replacement therapy). Participants will be recruited from four healthcare facilities in SA, receive 12 weeks of intervention and the primary outcome will be 7-day point prevalence tobacco abstinence from smoking at one year, measuring both exhaled breath carbon monoxide (CO) and urinary cotinine. A mixed methods approach will be used to evaluate implementation using the Reach, Effectiveness, Adoptions, Implementation, Maintenance framework. Cost, cost-effectiveness, and budget impact of each intervention combination will be evaluated. Conclusion: Results will inform which intervention components, and in what combination, are most efficacious in supporting smoking abstinence among PLWH in SA and those that have the greatest potential for effectiveness when brought to scale. Clinical Trial Registration Number: South African National Clinical Trials Registry. Trial No: DOH-27-062023-9076. ClinicalTrials.gov
AB - Background: Human immunodeficiency virus (HIV) remains an important cause of morbidity and mortality in South Africa (SA) with a gradual shift from opportunistic illness to pulmonary and cardiovascular disease among people living with HIV (PLWH). This shift is exacerbated by increases in prevalence of tobacco smoking and also few resources to support smoking cessation. Evidence-based smoking cessation strategies are yet to be fully evaluated among PLWH in this setting. Objective: This project will optimize a smoking cessation treatment package for PLWH that can be integrated into existing HIV care in SA. We will identify the most effective and/or combination of the interventions and evaluate their potential for implementation and cost-effectiveness. Methods: A balanced 24 full factorial clinical trial will randomise 660 PLWH who smoke tobacco into one of 16 combinations of four intervention components (behavioural counselling, peer counselling, varenicline, and combination nicotine replacement therapy). Participants will be recruited from four healthcare facilities in SA, receive 12 weeks of intervention and the primary outcome will be 7-day point prevalence tobacco abstinence from smoking at one year, measuring both exhaled breath carbon monoxide (CO) and urinary cotinine. A mixed methods approach will be used to evaluate implementation using the Reach, Effectiveness, Adoptions, Implementation, Maintenance framework. Cost, cost-effectiveness, and budget impact of each intervention combination will be evaluated. Conclusion: Results will inform which intervention components, and in what combination, are most efficacious in supporting smoking abstinence among PLWH in SA and those that have the greatest potential for effectiveness when brought to scale. Clinical Trial Registration Number: South African National Clinical Trials Registry. Trial No: DOH-27-062023-9076. ClinicalTrials.gov
UR - https://www.scopus.com/pages/publications/105008925617
UR - https://www.scopus.com/pages/publications/105008925617#tab=citedBy
U2 - 10.1016/j.cct.2025.107985
DO - 10.1016/j.cct.2025.107985
M3 - Article
C2 - 40543725
AN - SCOPUS:105008925617
SN - 1551-7144
VL - 155
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
M1 - 107985
ER -
