Evaluation of amphetamine-induced in vivo electrochemical response

Mark A. Dayton, Andrew G. Ewing, R. Mark Wightman

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


A carbon fiber microelectrode is shown to give a potential-dependent dopamine-selective response in rat brain tissue. However, distinct evidence for dopamine release is not obtained with intraperitoneal amphetamine administration (1.8 or 3.7 mg · kg-1). In rats which habe been unilaterally depleted of dopamine, the change in electrochemical signal obtained in the lesioned striatum is very similar to that measured on the non-lesioned side following amphetamine administration. This indicates that substances other than dopamine contribute to the observed signals.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number2-3
StatePublished - Oct 22 1981

All Science Journal Classification (ASJC) codes

  • Pharmacology


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