Evaluation of amphetamine-induced in vivo electrochemical response

Mark A. Dayton; Andrew G. Ewing; R. Mark Wightman

doi:10.1016/0014-2999(81)90074-1

Evaluation of amphetamine-induced in vivo electrochemical response

Mark A. Dayton
, Andrew G. Ewing
, R. Mark Wightman

Chemistry

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

A carbon fiber microelectrode is shown to give a potential-dependent dopamine-selective response in rat brain tissue. However, distinct evidence for dopamine release is not obtained with intraperitoneal amphetamine administration (1.8 or 3.7 mg · kg^-1). In rats which habe been unilaterally depleted of dopamine, the change in electrochemical signal obtained in the lesioned striatum is very similar to that measured on the non-lesioned side following amphetamine administration. This indicates that substances other than dopamine contribute to the observed signals.

Original language	English (US)
Pages (from-to)	141-144
Number of pages	4
Journal	European Journal of Pharmacology
Volume	75
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(81)90074-1
State	Published - Oct 22 1981

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1016/0014-2999(81)90074-1

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@article{c4940ea9346f42c7966da01e21648ee5,

title = "Evaluation of amphetamine-induced in vivo electrochemical response",

abstract = "A carbon fiber microelectrode is shown to give a potential-dependent dopamine-selective response in rat brain tissue. However, distinct evidence for dopamine release is not obtained with intraperitoneal amphetamine administration (1.8 or 3.7 mg · kg-1). In rats which habe been unilaterally depleted of dopamine, the change in electrochemical signal obtained in the lesioned striatum is very similar to that measured on the non-lesioned side following amphetamine administration. This indicates that substances other than dopamine contribute to the observed signals.",

author = "Dayton, \{Mark A.\} and Ewing, \{Andrew G.\} and \{Mark Wightman\}, R.",

note = "Funding Information: This work was supportedb y ResearchG rant NS 15841 from theN ationaIln stituteosf Healtha ndby ResearcGh rant BNS 77-38354fr omt heN ationaSl cienceF oundationM. :A.D. is a combinedM edical-Ph.Dc. andidateIn, dianaU niversity. R.M.W. is the recipienot f a ResearchC areerD evelopment Awardf romt heN ationaIln stituteosf Health( 1 K04 NS00356). The aid of G. Rebeca ndK. Allowayi n the6 -OHDA lesionsis gratefullayc knowledgeads,i s theg iftof a-MeDA fromM erck, Sharpea, ndDohme.",

year = "1981",

month = oct,

day = "22",

doi = "10.1016/0014-2999(81)90074-1",

language = "English (US)",

volume = "75",

pages = "141--144",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "2-3",

}

TY - JOUR

T1 - Evaluation of amphetamine-induced in vivo electrochemical response

AU - Dayton, Mark A.

AU - Ewing, Andrew G.

AU - Mark Wightman, R.

N1 - Funding Information: This work was supportedb y ResearchG rant NS 15841 from theN ationaIln stituteosf Healtha ndby ResearcGh rant BNS 77-38354fr omt heN ationaSl cienceF oundationM. :A.D. is a combinedM edical-Ph.Dc. andidateIn, dianaU niversity. R.M.W. is the recipienot f a ResearchC areerD evelopment Awardf romt heN ationaIln stituteosf Health( 1 K04 NS00356). The aid of G. Rebeca ndK. Allowayi n the6 -OHDA lesionsis gratefullayc knowledgeads,i s theg iftof a-MeDA fromM erck, Sharpea, ndDohme.

PY - 1981/10/22

Y1 - 1981/10/22

N2 - A carbon fiber microelectrode is shown to give a potential-dependent dopamine-selective response in rat brain tissue. However, distinct evidence for dopamine release is not obtained with intraperitoneal amphetamine administration (1.8 or 3.7 mg · kg-1). In rats which habe been unilaterally depleted of dopamine, the change in electrochemical signal obtained in the lesioned striatum is very similar to that measured on the non-lesioned side following amphetamine administration. This indicates that substances other than dopamine contribute to the observed signals.

AB - A carbon fiber microelectrode is shown to give a potential-dependent dopamine-selective response in rat brain tissue. However, distinct evidence for dopamine release is not obtained with intraperitoneal amphetamine administration (1.8 or 3.7 mg · kg-1). In rats which habe been unilaterally depleted of dopamine, the change in electrochemical signal obtained in the lesioned striatum is very similar to that measured on the non-lesioned side following amphetamine administration. This indicates that substances other than dopamine contribute to the observed signals.

UR - https://www.scopus.com/pages/publications/0019502978

UR - https://www.scopus.com/pages/publications/0019502978#tab=citedBy

U2 - 10.1016/0014-2999(81)90074-1

DO - 10.1016/0014-2999(81)90074-1

M3 - Article

C2 - 7318902

AN - SCOPUS:0019502978

SN - 0014-2999

VL - 75

SP - 141

EP - 144

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

Evaluation of amphetamine-induced in vivo electrochemical response

Abstract

All Science Journal Classification (ASJC) codes

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