TY - JOUR
T1 - Evaluation of Animal Models by Comparison with Human Late-Onset Alzheimer’s Disease
AU - Kim, Bu Yeo
AU - Lim, Hye Sun
AU - Kim, Yoonju
AU - Kim, Yu Jin
AU - Koo, Imhoi
AU - Jeong, Soo Jin
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Despite many efforts to alleviate the pathological conditions of Alzheimer’s disease (AD), effective therapeutic drugs have not been developed, mainly because of the lack of molecular information about AD and animal models. We observed the reciprocal regulation of AD-associated genes (AD genes) and their related functions. Upregulated AD genes were positioned in central regions in the protein–protein interaction network and were involved in inflammation and DNA repair pathways. Downregulated AD genes positioned in the periphery of the network were associated with metabolic pathways. Using these features of AD genes, we found that 5×FAD, amyloid β-injected mice, and rats in the initial phases after bilateral common carotid artery occlusion (BCCAO) exhibited patterns that were most similar to those of AD. In contrast, using differentially expressed genes from animal models, we observed that 3×Tg and animals in late phases of BCCAO were positioned close to AD genes.
AB - Despite many efforts to alleviate the pathological conditions of Alzheimer’s disease (AD), effective therapeutic drugs have not been developed, mainly because of the lack of molecular information about AD and animal models. We observed the reciprocal regulation of AD-associated genes (AD genes) and their related functions. Upregulated AD genes were positioned in central regions in the protein–protein interaction network and were involved in inflammation and DNA repair pathways. Downregulated AD genes positioned in the periphery of the network were associated with metabolic pathways. Using these features of AD genes, we found that 5×FAD, amyloid β-injected mice, and rats in the initial phases after bilateral common carotid artery occlusion (BCCAO) exhibited patterns that were most similar to those of AD. In contrast, using differentially expressed genes from animal models, we observed that 3×Tg and animals in late phases of BCCAO were positioned close to AD genes.
UR - http://www.scopus.com/inward/record.url?scp=85045243971&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045243971&partnerID=8YFLogxK
U2 - 10.1007/s12035-018-1036-6
DO - 10.1007/s12035-018-1036-6
M3 - Article
C2 - 29656362
AN - SCOPUS:85045243971
SN - 0893-7648
VL - 55
SP - 9234
EP - 9250
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 12
ER -