Evaluation of anti-ulcer properties of the leaf extract of Juniperus communis L. in animals

Objective: The purpose of this present study is to elicit the anti-ulcer property of Juniperus communis (Linn.). Materials and Methods: In the present communication, models of acetyl salicylic acid, serotonin, indomethacin, alcohol and stress-induced gastric ulcerations in rats and histamine-induced duodenal lesions in guinea pigs were adopted to study the anti-ulcer activity of the extract. Biochemical parameters like pH, total acidity and peptic acidity of the gastric juice was also studied. Results: The crude leaf extract at doses of 50 mg and 100 mg/kg (i.p) significantly inhibited aspirin, serotonin, indomethacin, alcohol and stress-induced gastric ulcerations in rats and histamine-induced duodenal lesions in guinea pigs. The healing rate of acetic acid induced ulcer in rats was also enhanced significantly by the leaf extract. The results were at par with the standard drug ranitidine. Biochemical analysis of gastric juice revealed that the extract significantly decreased its volume and total acidity, but did not alter its pH and peptic activity. Conclusion: The present study revealed that the leaf extract of J. communis is a potent ulcer pain reliever and also promotes healing, which are the two ultimate goals of therapy for ulcers.