Evaluation of HL-20 roller pump and rotaflow centrifugal pump on perfusion quality and gaseous microemboli delivery

Stella Yee, Feng Qiu, Xiaowei Su, Alan Rider, Allen Kunselman, Yulong Guan, Akif Undar

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The purpose of this study was to compare the HL-20 roller pump (Jostra USA, Austin, TX, USA) and Rotaflow centrifugal pump (Jostra USA) on hemodynamic energy production and gaseous microemboli (GME) delivery in a simulated neonatal cardiopulmonary bypass (CPB) circuit under nonpulsatile perfusion. This study employed a simulated model of the pediatric CPB including a Jostra HL-20 heart-lung machine (or a Rotaflow centrifugal pump), a Capiox BabyRX05 oxygenator (Terumo Corporation, Tokyo, Japan), a Capiox pediatric arterial filter (Terumo Corporation), and 1/4-inch tubing. The total volume of the experimental system was 700-mL (500-mL for the circuit and 200-mL for the pseudo neonatal patient). The hematocrit was maintained at 30% using human blood. At the beginning of each trial, a 5-mL bolus of air was injected into the venous line. Both GME data and pressure values were recorded at postpump and postoxygenator sites. All the experiments were conducted under nonpulsatile perfusion at three flow rates (500, 750, and 1000-mL/min) and three blood temperatures (35, 30, and 25°C). As n-=-6 for each setup, a total of 108 trials were done. The total number of GME increased as temperature decreased from 35°C to 25°C in the trials using the HL-20 roller pump while the opposite effect occurred when using the Rotaflow centrifugal pump. At a given temperature, total GME counts increased with increasing flow rates for both pumps. Results indicated the Rotaflow centrifugal pump delivered significantly fewer microemboli compared to the HL-20 roller pump, especially under high flow rates. Less than 10% of total microemboli were larger than 40-μm in size and the majority of GME were in the 0-20-μm class in all trials. Postpump total hemodynamic energy (THE) increased with increasing flow rates and decreasing temperatures in both circuits using these two pumps. The HL-20 roller pump delivered more THE than the Rotaflow centrifugal pump at all tested flow rates and temperature conditions. Results suggest the HL-20 roller pump delivers more GME than the Rotaflow centrifugal pump but produces more hemodynamic energy under nonpulsatile perfusion mode.

Original languageEnglish (US)
Pages (from-to)937-943
Number of pages7
JournalArtificial organs
Issue number11
StatePublished - Nov 2010

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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