Evaluation of repeat daily voiding measures in the national interstitial cystitis data base study

Carissa A. Mazurick, J. Richard Landis, Alan J. Wein, Marilou Foy, Philip M. Hanno, Frederick Monson, Denise Nigro, Kristene E. Whitmore, C. Lowell Parsons, Paul Stein, Stephanie Larison, Mary Williams, Diana LeBow, Daniel J. Culkin, Johnny B. Roy, Robert E. Hurst, Lori Mulrooney, Linda Walker, Anthony Schaeffer, Mary NeiweglowskiGwen Maurer, David T. Uehling, Edward M. Messing, Diane Pauk, Ananias C. Diokno, Alexandre Afanasyev, Eleanor Anton, Bruce W. Steinert, Aaron Kirkemo, David Burks, Michelle Peabody, Yvonne L. Matthews Cook, Laura J. Simon, Deborah Erickson, Douglas W. Gray, Allen R. Kunselman, Brenda Phillips, Susan J. Boehmer, Suzanne Trosko Abele, Amy Paynter, Patricia Rawa, Elizabeth Phillips, Brenda Beers, Randy Hilderbrand, Kathleen J. Propert, Mary D. Sammel, Lan Zhou, Jesse L. Chittams, Christine Hardy, Colleen Brensinger, Lori Ann Smith, Janet Staley, Michael Kallan, Rosemarie Mick, Amy B. Hillanbrand, Steve Durborow, Asenath Miligan, John E. Tomaszewski, Li Pang Wang, Thomas William, Leroy M. Nyberg, John W. Kusek, Camille Jones, Michael O'Leary

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Purpose: We address the importance of 3 consecutive daily frequency volume charts relative to a single day in research studies for interstitial cystitis. In addition, differences in voiding patterns between weekend days and weekdays were evaluated. Materials and Methods: Longitudinal frequency volume chart data for 305 women enrolled in the National Interstitial Cystitis Data Base Study before December 31, 1995 and meeting protocol specifications were summarized for 3 outcome measures. Longitudinal data methods designed to accommodate different within patient correlation patterns for repeat measures within and among patient contacts were implemented in a generalized estimating equation modeling framework, permitting overall testing of day and weekend effects. Results: Day 2 and day 3 measures were not statistically different (1% level) from day 1 for nocturnal voiding frequency and nocturia. Although statistically significant for 24-hour frequency, the mean difference of -0.36 void daily between days 1 and 3 was not likely to be clinically significant. Also, measures on weekdays were not significantly different from those on weekends for each of the 3 outcome measures. Conclusions: Our results suggest that the current clinical research requirement of 3 consecutive days for frequency volume charts can be reduced to a single day. Furthermore, day selection need not be affected by weekday versus weekend considerations.

Original languageEnglish (US)
Pages (from-to)1208-1211
Number of pages4
JournalJournal of Urology
Issue number4
StatePublished - Apr 2000

All Science Journal Classification (ASJC) codes

  • Urology


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