Evaluation of the Importance of Hydrophobic Interactions in Drug Binding to Dihydrofolate Reductase

Medicine & Life Sciences

• Tetrahydrofolate Dehydrogenase 100%
• Hydrophobic and Hydrophilic Interactions 82%
• Methotrexate 60%
• Pharmaceutical Preparations 30%
• dihydrofolate 21%
• Mutation 20%
• Pteridines 20%
• Fluorescence Spectrometry 15%
• Valine 14%
• Phenylalanine 13%
• NADP 13%
• Tyrosine 11%
• Salts 10%
• Binding Sites 9%
• Kinetics 9%
• Escherichia coli 8%
• Amino Acids 8%
• 2,4-diamino-6,7-dimethylpteridine 1%

Chemical Compounds

• Methotrexate 77%
• Drug 39%
• Mutation 31%
• Dissociation Constant 23%
• Pteridine 17%
• Valine 13%
• Site-Directed Mutagenesis 12%
• Tyrosine 11%
• Fluorescence Spectroscopy 11%
• Binding Energy 10%
• Binding Site 8%
• Acid 4%