Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer

Tian Yu; John Bachman; Zhi Chun Lai

doi:10.1534/genetics.113.156372

Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer

Tian Yu, John Bachman, Zhi Chun Lai

Research output: Contribution to journal › Comment/debate › peer-review

28 Scopus citations

Abstract

The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

Original language	English (US)
Pages (from-to)	1193-1196
Number of pages	4
Journal	Genetics
Volume	195
Issue number	3
DOIs	https://doi.org/10.1534/genetics.113.156372
State	Published - 2013

All Science Journal Classification (ASJC) codes

General Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1534/genetics.113.156372

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title = "Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer",

abstract = "The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.",

author = "Tian Yu and John Bachman and Lai, {Zhi Chun}",

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AU - Bachman, John

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N2 - The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

AB - The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

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Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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