Abstract
The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.
Original language | English (US) |
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Pages (from-to) | 1193-1196 |
Number of pages | 4 |
Journal | Genetics |
Volume | 195 |
Issue number | 3 |
DOIs |
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State | Published - 2013 |
All Science Journal Classification (ASJC) codes
- General Medicine