Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer

Tian Yu; John Bachman; Zhi Chun Lai

doi:10.1534/genetics.113.156372

Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer

Tian Yu
, John Bachman
, Zhi Chun Lai

Research output: Contribution to journal › Comment/debate › peer-review

28 Scopus citations

Abstract

The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

Original language	English (US)
Pages (from-to)	1193-1196
Number of pages	4
Journal	Genetics
Volume	195
Issue number	3
DOIs	https://doi.org/10.1534/genetics.113.156372
State	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1534/genetics.113.156372

Cite this

@article{13e581a0f8864fb9ad3a815c02d59e64,

title = "Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer",

abstract = "The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.",

author = "Tian Yu and John Bachman and Lai, \{Zhi Chun\}",

year = "2013",

doi = "10.1534/genetics.113.156372",

language = "English (US)",

volume = "195",

pages = "1193--1196",

journal = "Genetics",

issn = "0016-6731",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer

AU - Yu, Tian

AU - Bachman, John

AU - Lai, Zhi Chun

PY - 2013

Y1 - 2013

N2 - The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

AB - The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

UR - https://www.scopus.com/pages/publications/84887058426

UR - https://www.scopus.com/pages/publications/84887058426#tab=citedBy

U2 - 10.1534/genetics.113.156372

DO - 10.1534/genetics.113.156372

M3 - Comment/debate

C2 - 24026096

AN - SCOPUS:84887058426

SN - 0016-6731

VL - 195

SP - 1193

EP - 1196

JO - Genetics

JF - Genetics

IS - 3

ER -

Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this