Abstract
We report on the presence of progesterone receptor and its mRNA in a human osteoblast-like cell line (HOS TE85) using recombinant DNA methods, saturation analysis, specific immunoprecipitation with an anti-progesterone receptor antibody, and Northern blot analysis. These osteoblast-like cells were also found to be responsive to progesterone in a dose-dependent fashion through an augmentation in cellular alkaline phosphatase activity. These results support the presence of progesterone receptors in bone cells and suggest a direct effort of progesterone and/or antiprogestins on osteoblast cell function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 525-532 |
| Number of pages | 8 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 195 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 15 1993 |
All Science Journal Classification (ASJC) codes
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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