Evidence that molecules on the surface of one cell can adhere to the oligosaccharide portion of gangliosides on the surface of another cell

Cara Lynne Schengrund

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations

    Abstract

    While there have been numerous reports concerning the possible role(s) of gangliosides in neuronal development and their efficacy, or lack thereof, as possible therapeutic agents for the treatment of neuronal injury, the molecular mechanisms by which they induce specific cellular effects are not well understood. This review presents evidence for the existence of cell surface molecules able to adhere to the oligosaccharide portion of specific gangliosides and describes methods employed for their study. The identification of such cell surface molecules permits the hypothesis that the binding of the oligosaccharide portion of the ganglioside by its cell surface receptor is responsible for initiating the intracellular reactions that lead to modified cell behavior.

    Original languageEnglish (US)
    Pages (from-to)1-13
    Number of pages13
    JournalNeuroSignals
    Volume4
    Issue number1
    DOIs
    StatePublished - 1995

    All Science Journal Classification (ASJC) codes

    • Neurology
    • Developmental Neuroscience
    • Cellular and Molecular Neuroscience

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