TY - JOUR
T1 - Evolution of chordate Hox gene clusters
AU - Ruddle, Frank H.
AU - Amemiya, Chris T.
AU - Carr, Janet L.
AU - Kim, Chang Bae
AU - Ledje, Christina
AU - Shashikant, Cooduvalli S.
AU - Wagner, Günter P.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - In this article, we consider the role of the Hox genes in chordate and vertebrate evolution from the viewpoints of molecular and developmental evolution. Models of Hox cluster duplication are considered with emphasis on a threefold duplication model. We also show that cluster duplication is consistent with a semiconservative model of duplication, where following duplication, one daughter cluster remains unmodified, while the other diverges and assumes a new architecture and presumably new functions. Evidence is reviewed, suggesting that Hox gene enhancers have played an important role in body plan evolution. Finally, we contrast the invertebrates and vertebrates in terms of genome and Hox cluster duplication which are present in the latter, but not the former. We question whether gene duplication has been important in vertebrates for the introduction of novel features such as limbs, a urogenital system, and specialized neuromuscular interactions.
AB - In this article, we consider the role of the Hox genes in chordate and vertebrate evolution from the viewpoints of molecular and developmental evolution. Models of Hox cluster duplication are considered with emphasis on a threefold duplication model. We also show that cluster duplication is consistent with a semiconservative model of duplication, where following duplication, one daughter cluster remains unmodified, while the other diverges and assumes a new architecture and presumably new functions. Evidence is reviewed, suggesting that Hox gene enhancers have played an important role in body plan evolution. Finally, we contrast the invertebrates and vertebrates in terms of genome and Hox cluster duplication which are present in the latter, but not the former. We question whether gene duplication has been important in vertebrates for the introduction of novel features such as limbs, a urogenital system, and specialized neuromuscular interactions.
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U2 - 10.1111/j.1749-6632.1999.tb08884.x
DO - 10.1111/j.1749-6632.1999.tb08884.x
M3 - Article
C2 - 10415487
AN - SCOPUS:0032796625
SN - 0077-8923
VL - 870
SP - 238
EP - 248
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -