Evolution of gametocyte sex ratios in malaria and related apicomplexan (protozoan) parasites

Stuart A. West; Sarah E. Reece; Andrew F. Read

doi:10.1016/S1471-4922(01)02058-X

Evolution of gametocyte sex ratios in malaria and related apicomplexan (protozoan) parasites

Stuart A. West, Sarah E. Reece, Andrew F. Read

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

'Survival of the fittest' is usually interpreted to mean that natural selection favours genes that maximize their transmission to the next generation. Here, we discuss recent applications of this principle to the study of gametocyte sex ratios in malaria and other apicomplexan parasites. Sex ratios matter because they are an important determinant of fitness and transmission success - and hence of disease epidemiology and evolution. Moreover, inbreeding rates can be estimated from gametocyte sex ratios. The sex ratio is also an excellent model trait for testing the validity of important components of what is being marketed as 'Darwinian medicine'.

Original language	English (US)
Pages (from-to)	525-531
Number of pages	7
Journal	Trends in Parasitology
Volume	17
Issue number	11
DOIs	https://doi.org/10.1016/S1471-4922(01)02058-X
State	Published - Nov 1 2001

All Science Journal Classification (ASJC) codes

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1471-4922(01)02058-X

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abstract = "'Survival of the fittest' is usually interpreted to mean that natural selection favours genes that maximize their transmission to the next generation. Here, we discuss recent applications of this principle to the study of gametocyte sex ratios in malaria and other apicomplexan parasites. Sex ratios matter because they are an important determinant of fitness and transmission success - and hence of disease epidemiology and evolution. Moreover, inbreeding rates can be estimated from gametocyte sex ratios. The sex ratio is also an excellent model trait for testing the validity of important components of what is being marketed as 'Darwinian medicine'.",

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AU - Reece, Sarah E.

AU - Read, Andrew F.

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N2 - 'Survival of the fittest' is usually interpreted to mean that natural selection favours genes that maximize their transmission to the next generation. Here, we discuss recent applications of this principle to the study of gametocyte sex ratios in malaria and other apicomplexan parasites. Sex ratios matter because they are an important determinant of fitness and transmission success - and hence of disease epidemiology and evolution. Moreover, inbreeding rates can be estimated from gametocyte sex ratios. The sex ratio is also an excellent model trait for testing the validity of important components of what is being marketed as 'Darwinian medicine'.

AB - 'Survival of the fittest' is usually interpreted to mean that natural selection favours genes that maximize their transmission to the next generation. Here, we discuss recent applications of this principle to the study of gametocyte sex ratios in malaria and other apicomplexan parasites. Sex ratios matter because they are an important determinant of fitness and transmission success - and hence of disease epidemiology and evolution. Moreover, inbreeding rates can be estimated from gametocyte sex ratios. The sex ratio is also an excellent model trait for testing the validity of important components of what is being marketed as 'Darwinian medicine'.

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Evolution of gametocyte sex ratios in malaria and related apicomplexan (protozoan) parasites

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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