Evolution of placental invasion and cancer metastasis are causally linked

Kshitiz; Junaid Afzal; Jamie D. Maziarz; Archer Hamidzadeh; Cong Liang; Eric M. Erkenbrack; Hong Nam; Jan Dirk Haeger; Christiane Pfarrer; Thomas Hoang; Troy Ott; Thomas Spencer; Mihaela Pavličev; Douglas F. Antczak; Andre Levchenko; Günter P. Wagner

doi:10.1038/s41559-019-1046-4

Evolution of placental invasion and cancer metastasis are causally linked

Kshitiz, Junaid Afzal, Jamie D. Maziarz, Archer Hamidzadeh, Cong Liang, Eric M. Erkenbrack, Hong Nam, Jan Dirk Haeger, Christiane Pfarrer, Thomas Hoang, Troy Ott, Thomas Spencer, Mihaela Pavličev, Douglas F. Antczak, Andre Levchenko, Günter P. Wagner

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Among mammals, placental invasion is correlated with vulnerability to malignancy. Animals with more invasive placentation (for example, humans) are more vulnerable to malignancy. To explain this correlation, we propose the hypothesis of ‘Evolved Levels of Invasibility’ proposing that the evolution of invasibility of stromal tissue affects both placental and cancer invasion. We provide evidence for this using an in vitro model. We find that bovine endometrial and skin fibroblasts are more resistant to invasion than are their human counterparts. Gene expression profiling identified genes with high expression in human but not in bovine fibroblasts. Knocking down a subset of them in human fibroblasts leads to stronger resistance to cancer cell invasion. Identifying the evolutionary determinants of stromal invasibility can provide important insights to develop rational antimetastatic therapeutics.

Original language	English (US)
Pages (from-to)	1743-1753
Number of pages	11
Journal	Nature Ecology and Evolution
Volume	3
Issue number	12
DOIs	https://doi.org/10.1038/s41559-019-1046-4
State	Published - Dec 1 2019

All Science Journal Classification (ASJC) codes

Ecology, Evolution, Behavior and Systematics
Ecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41559-019-1046-4

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Kshitiz, Afzal, J., Maziarz, J. D., Hamidzadeh, A., Liang, C., Erkenbrack, E. M., Nam, H., Haeger, J. D., Pfarrer, C., Hoang, T., Ott, T., Spencer, T., Pavličev, M., Antczak, D. F., Levchenko, A., & Wagner, G. P. (2019). Evolution of placental invasion and cancer metastasis are causally linked. Nature Ecology and Evolution, 3(12), 1743-1753. https://doi.org/10.1038/s41559-019-1046-4

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title = "Evolution of placental invasion and cancer metastasis are causally linked",

abstract = "Among mammals, placental invasion is correlated with vulnerability to malignancy. Animals with more invasive placentation (for example, humans) are more vulnerable to malignancy. To explain this correlation, we propose the hypothesis of {\textquoteleft}Evolved Levels of Invasibility{\textquoteright} proposing that the evolution of invasibility of stromal tissue affects both placental and cancer invasion. We provide evidence for this using an in vitro model. We find that bovine endometrial and skin fibroblasts are more resistant to invasion than are their human counterparts. Gene expression profiling identified genes with high expression in human but not in bovine fibroblasts. Knocking down a subset of them in human fibroblasts leads to stronger resistance to cancer cell invasion. Identifying the evolutionary determinants of stromal invasibility can provide important insights to develop rational antimetastatic therapeutics.",

author = "Kshitiz and Junaid Afzal and Maziarz, {Jamie D.} and Archer Hamidzadeh and Cong Liang and Erkenbrack, {Eric M.} and Hong Nam and Haeger, {Jan Dirk} and Christiane Pfarrer and Thomas Hoang and Troy Ott and Thomas Spencer and Mihaela Pavli{\v c}ev and Antczak, {Douglas F.} and Andre Levchenko and Wagner, {G{\"u}nter P.}",

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doi = "10.1038/s41559-019-1046-4",

language = "English (US)",

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Kshitiz, Afzal, J, Maziarz, JD, Hamidzadeh, A, Liang, C, Erkenbrack, EM, Nam, H, Haeger, JD, Pfarrer, C, Hoang, T, Ott, T, Spencer, T, Pavličev, M, Antczak, DF, Levchenko, A & Wagner, GP 2019, 'Evolution of placental invasion and cancer metastasis are causally linked', Nature Ecology and Evolution, vol. 3, no. 12, pp. 1743-1753. https://doi.org/10.1038/s41559-019-1046-4

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AU - Kshitiz,

AU - Afzal, Junaid

AU - Maziarz, Jamie D.

AU - Hamidzadeh, Archer

AU - Liang, Cong

AU - Erkenbrack, Eric M.

AU - Nam, Hong

AU - Haeger, Jan Dirk

AU - Pfarrer, Christiane

AU - Hoang, Thomas

AU - Ott, Troy

AU - Spencer, Thomas

AU - Pavličev, Mihaela

AU - Antczak, Douglas F.

AU - Levchenko, Andre

AU - Wagner, Günter P.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Among mammals, placental invasion is correlated with vulnerability to malignancy. Animals with more invasive placentation (for example, humans) are more vulnerable to malignancy. To explain this correlation, we propose the hypothesis of ‘Evolved Levels of Invasibility’ proposing that the evolution of invasibility of stromal tissue affects both placental and cancer invasion. We provide evidence for this using an in vitro model. We find that bovine endometrial and skin fibroblasts are more resistant to invasion than are their human counterparts. Gene expression profiling identified genes with high expression in human but not in bovine fibroblasts. Knocking down a subset of them in human fibroblasts leads to stronger resistance to cancer cell invasion. Identifying the evolutionary determinants of stromal invasibility can provide important insights to develop rational antimetastatic therapeutics.

AB - Among mammals, placental invasion is correlated with vulnerability to malignancy. Animals with more invasive placentation (for example, humans) are more vulnerable to malignancy. To explain this correlation, we propose the hypothesis of ‘Evolved Levels of Invasibility’ proposing that the evolution of invasibility of stromal tissue affects both placental and cancer invasion. We provide evidence for this using an in vitro model. We find that bovine endometrial and skin fibroblasts are more resistant to invasion than are their human counterparts. Gene expression profiling identified genes with high expression in human but not in bovine fibroblasts. Knocking down a subset of them in human fibroblasts leads to stronger resistance to cancer cell invasion. Identifying the evolutionary determinants of stromal invasibility can provide important insights to develop rational antimetastatic therapeutics.

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Evolution of placental invasion and cancer metastasis are causally linked

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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