TY - JOUR
T1 - Evolution via somatic genetic variation in modular species
AU - Reusch, Thorsten B.H.
AU - Baums, Iliana B.
AU - Werner, Benjamin
N1 - Funding Information:
This work has been funded by the Human Frontiers of Science Program (HFSP), grant number RGP0042_2020 to I.B.B., B.W., and T.B.H.R. and through the DFG-Research Training Group 'TransEvo - Translational Evolutionary Research' RTG2501 to T.B.H.R. We thank Susanne Landis for illustrations and Hinrich Schulenburg and Tal Dagan for helpful comments on an earlier version of the manuscript.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12
Y1 - 2021/12
N2 - Somatic genetic variation (SoGV) may play a consequential yet underappreciated role in long-lived, modular species among plants, animals, and fungi. Recent genomic data identified two levels of genetic heterogeneity, between cell lines and between modules, that are subject to multilevel selection. Because SoGV can transfer into gametes when germlines are sequestered late in ontogeny (plants, algae, and fungi and some basal animals), sexual and asexual processes provide interdependent routes of mutational input and impact the accumulation of genetic load and molecular evolution rates of the integrated asexual/sexual life cycle. Avenues for future research include possible fitness effects of SoGV, the identification and implications of multilevel selection, and modeling of asexual selective sweeps using approaches from tumor evolution.
AB - Somatic genetic variation (SoGV) may play a consequential yet underappreciated role in long-lived, modular species among plants, animals, and fungi. Recent genomic data identified two levels of genetic heterogeneity, between cell lines and between modules, that are subject to multilevel selection. Because SoGV can transfer into gametes when germlines are sequestered late in ontogeny (plants, algae, and fungi and some basal animals), sexual and asexual processes provide interdependent routes of mutational input and impact the accumulation of genetic load and molecular evolution rates of the integrated asexual/sexual life cycle. Avenues for future research include possible fitness effects of SoGV, the identification and implications of multilevel selection, and modeling of asexual selective sweeps using approaches from tumor evolution.
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U2 - 10.1016/j.tree.2021.08.011
DO - 10.1016/j.tree.2021.08.011
M3 - Review article
C2 - 34538501
AN - SCOPUS:85115030335
SN - 0169-5347
VL - 36
SP - 1083
EP - 1092
JO - Trends in Ecology and Evolution
JF - Trends in Ecology and Evolution
IS - 12
ER -