TY - JOUR
T1 - Ex-vivo analysis of the bone microenvironment in bone metastatic breast cancer
AU - Bussard, Karen M.
AU - Mastro, Andrea M.
PY - 2009/12
Y1 - 2009/12
N2 - In humans, breast cancer has a predilection to metastasize to the skeleton. While the mechanism for preferential metastasis is unknown, the bone microenvironment likely provides a fertile soil for metastatic breast cancer cells. In order to examine the bone microenvironment ex-vivo following the formation of breast cancer metastases, several techniques may be employed: fluorescence stereomicroscopy, magnetic resonance imaging (MRI), microCT (μCT), immunohistochemistry, and cytokine arrays, to name a few. These methods allow for a comprehensive evaluation of the bone microenvironment during bone metastatic breast cancer. By identifying alterations in the bone niche caused by metastatic breast cancer cells, it may be possible to block or disrupt these factors through the use of targeted drugs. Appropriate therapeutic treatment would allow for an improved quality of life and longer survival time for individuals with bone metastatic breast cancer.
AB - In humans, breast cancer has a predilection to metastasize to the skeleton. While the mechanism for preferential metastasis is unknown, the bone microenvironment likely provides a fertile soil for metastatic breast cancer cells. In order to examine the bone microenvironment ex-vivo following the formation of breast cancer metastases, several techniques may be employed: fluorescence stereomicroscopy, magnetic resonance imaging (MRI), microCT (μCT), immunohistochemistry, and cytokine arrays, to name a few. These methods allow for a comprehensive evaluation of the bone microenvironment during bone metastatic breast cancer. By identifying alterations in the bone niche caused by metastatic breast cancer cells, it may be possible to block or disrupt these factors through the use of targeted drugs. Appropriate therapeutic treatment would allow for an improved quality of life and longer survival time for individuals with bone metastatic breast cancer.
UR - http://www.scopus.com/inward/record.url?scp=75149153234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75149153234&partnerID=8YFLogxK
U2 - 10.1007/s10911-009-9159-z
DO - 10.1007/s10911-009-9159-z
M3 - Article
C2 - 19949843
AN - SCOPUS:75149153234
SN - 1083-3021
VL - 14
SP - 387
EP - 395
JO - Journal of mammary gland biology and neoplasia
JF - Journal of mammary gland biology and neoplasia
IS - 4
ER -
