Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression

Meghan E. Carey, Juliette Rando, Stepan Melnyk, S. Jill James, Nathaniel Snyder, Carolyn Salafia, Lisa A. Croen, M. Daniele Fallin, Irva Hertz-Picciotto, Heather Volk, Craig Newschaffer, Kristen Lyall

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling’s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.

Original languageEnglish (US)
Pages (from-to)2975-2985
Number of pages11
JournalJournal of Autism and Developmental Disorders
Volume53
Issue number8
DOIs
StatePublished - Aug 2023

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology

Fingerprint

Dive into the research topics of 'Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression'. Together they form a unique fingerprint.

Cite this