Exercise enhances vaccine-induced antigen-specific T cell responses

Connie J. Rogers; David A. Zaharoff; Kenneth W. Hance; Susan N. Perkins; Stephen D. Hursting; Jeffrey Schlom; John W. Greiner

doi:10.1016/j.vaccine.2008.07.081

Exercise enhances vaccine-induced antigen-specific T cell responses

Connie J. Rogers
, David A. Zaharoff
, Kenneth W. Hance
, Susan N. Perkins
, Stephen D. Hursting
, Jeffrey Schlom
, John W. Greiner

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4⁺ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.

Original language	English (US)
Pages (from-to)	5407-5415
Number of pages	9
Journal	Vaccine
Volume	26
Issue number	42
DOIs	https://doi.org/10.1016/j.vaccine.2008.07.081
State	Published - Oct 3 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2008.07.081

Cite this

@article{664719eb72114b0cbec7c56cacd4402a,

title = "Exercise enhances vaccine-induced antigen-specific T cell responses",

abstract = "Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4+ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.",

author = "Rogers, \{Connie J.\} and Zaharoff, \{David A.\} and Hance, \{Kenneth W.\} and Perkins, \{Susan N.\} and Hursting, \{Stephen D.\} and Jeffrey Schlom and Greiner, \{John W.\}",

note = "Funding Information: This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, and by the National Cancer Institute Cancer Prevention Fellowship Program. This work was also supported by funding to S. Hursting from NIEHS \# P30 ES007784 and the Breast Cancer Research Foundation. ",

year = "2008",

month = oct,

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doi = "10.1016/j.vaccine.2008.07.081",

language = "English (US)",

volume = "26",

pages = "5407--5415",

journal = "Vaccine",

issn = "0264-410X",

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number = "42",

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TY - JOUR

T1 - Exercise enhances vaccine-induced antigen-specific T cell responses

AU - Rogers, Connie J.

AU - Zaharoff, David A.

AU - Hance, Kenneth W.

AU - Perkins, Susan N.

AU - Hursting, Stephen D.

AU - Schlom, Jeffrey

AU - Greiner, John W.

N1 - Funding Information: This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, and by the National Cancer Institute Cancer Prevention Fellowship Program. This work was also supported by funding to S. Hursting from NIEHS # P30 ES007784 and the Breast Cancer Research Foundation.

PY - 2008/10/3

Y1 - 2008/10/3

N2 - Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4+ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.

AB - Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4+ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.

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UR - https://www.scopus.com/pages/publications/51549096347#tab=citedBy

U2 - 10.1016/j.vaccine.2008.07.081

DO - 10.1016/j.vaccine.2008.07.081

M3 - Article

C2 - 18706954

AN - SCOPUS:51549096347

SN - 0264-410X

VL - 26

SP - 5407

EP - 5415

JO - Vaccine

JF - Vaccine

IS - 42

ER -

Exercise enhances vaccine-induced antigen-specific T cell responses

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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