TY - JOUR
T1 - Existing and emerging mechanisms for transport of iron and manganese to the brain
AU - Malecki, Elise A.
AU - Devenyi, Attila G.
AU - Beard, John L.
AU - Connor, James
PY - 1999/5/1
Y1 - 1999/5/1
N2 - The metals iron (Fe) and manganese (Mn) are essential for normal functioning of the brain. This review focuses on recent developments in the literature pertaining to Fe and Mn transport. These metals are treated together because they appear to share several transport mechanisms. In addition, several neurological diseases such as Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease are all associated with Fe mismanagement in the brain, particularly in the striatum and basal ganglia. Similarly, Mn accumulation in brain also appears to target the same brain regions. Therefore, stringent regulation of the concentration of these metals in the brain is essential. The homeostatic mechanisms for these metals must be understood in order to design neurotoxicity prevention strategies.
AB - The metals iron (Fe) and manganese (Mn) are essential for normal functioning of the brain. This review focuses on recent developments in the literature pertaining to Fe and Mn transport. These metals are treated together because they appear to share several transport mechanisms. In addition, several neurological diseases such as Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease are all associated with Fe mismanagement in the brain, particularly in the striatum and basal ganglia. Similarly, Mn accumulation in brain also appears to target the same brain regions. Therefore, stringent regulation of the concentration of these metals in the brain is essential. The homeostatic mechanisms for these metals must be understood in order to design neurotoxicity prevention strategies.
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U2 - 10.1002/(sici)1097-4547(19990415)56:2<113::aid-jnr1>3.0.co;2-k
DO - 10.1002/(sici)1097-4547(19990415)56:2<113::aid-jnr1>3.0.co;2-k
M3 - Short survey
C2 - 10777372
AN - SCOPUS:0033134765
SN - 0360-4012
VL - 56
SP - 113
EP - 122
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
IS - 2
ER -