Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

Keyphrases

• Genetic Architecture 100%
• Meta-analysis 100%
• Alcohol Use 100%
• Rare Coding Variants 100%
• Exome chip 100%
• Causal Variant 100%
• Fine Mapping 66%
• Rare Variants 66%
• Heritability 66%
• Exome Array 66%
• Nonsynonymous 66%
• Genotype 33%
• Metaanalysis 33%
• Genome-wide Association Study 33%
• Functional Consequences 33%
• Single nucleotide Polymorphism 33%
• Substance Use Behaviors 33%
• Genotype Imputation 33%
• Multiple Variants 33%
• Loss Function 33%
• Pack-years 33%
• Gain-of-function mutation 33%
• Phenotypic Variance 33%
• Biological Mechanisms 33%
• Multiple Loci 33%
• Disease Risk 33%
• Gene-based 33%
• Smoking Initiation 33%
• Common Genetic Variants 33%
• Alcoholic Beverages 33%
• Double Base 33%
• Imputed Data 33%
• Cigarettes per Day 33%
• Heritability Analysis 33%
• Coding Variants 33%
• Age of Initiation 33%
• Burden Test 33%
• UK Biobank 33%
• Function Code 33%
• Fine-mapping Analysis 33%
• Biological Aetiology 33%
• Test-based 33%
• Base-pair Resolution 33%
• 95% Confidence Interval 33%

Biochemistry, Genetics and Molecular Biology

• Genetic Architecture 100%
• Exome 100%
• Substance Use 66%
• Rare Variant 66%
• Genotyping 33%
• Genetic Divergence 33%
• Genome-Wide Association Study 33%
• Single-Nucleotide Polymorphism 33%
• Sample Size 33%
• Genotype Imputation 33%