Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes

Keyphrases

• Disease Genes 100%
• Degenerative Disease 100%
• Senescence-accelerated Mouse 100%
• Deleterious mutations 100%
• Exome Sequencing 100%
• Osteoporosis 66%
• Missense mutation 66%
• Distal Hereditary Motor Neuropathy (dHMN) 66%
• Mouse Strain 33%
• Whole Exome Sequencing 33%
• In(III) 33%
• Senescence 33%
• Coding Region 33%
• Inbred Strains 33%
• Single nucleotide Variant 33%
• Gene mutation 33%
• Resistant Strains 33%
• Ulcerative Colitis 33%
• SAMP10 33%
• Brain Atrophy 33%
• Frameshift mutation 33%
• Aging Research 33%
• Aging Characteristics 33%
• Senescence-Accelerated Mice Strains 33%
• Short Lifetime 33%
• Mutation Specific 33%
• Responsible Gene 33%
• Immune Dysfunction 33%
• OGG1 33%

Neuroscience

• Missense Mutation 100%
• Exome Sequencing 100%
• Single-Nucleotide Polymorphism 50%
• Gene Mutation 50%
• Coding Region 50%
• Muscle Disorder 50%
• Peripheral Neuropathy 50%

Biochemistry, Genetics and Molecular Biology

• Exome Sequencing 100%
• Missense Mutation 66%
• Mouse Strain 66%
• Mouse 33%
• Single-Nucleotide Polymorphism 33%
• Coding Region 33%
• Inbred Strain 33%
• Gene Mutation 33%
• Lifespan 33%