TY - JOUR
T1 - Expanding protein universe and its origin from the biological Big Bang
AU - Dokholyan, Nikolay V.
AU - Shakhnovich, Boris
AU - Shakhnovich, Eugene I.
PY - 2002/10/29
Y1 - 2002/10/29
N2 - The bottom-up approach to understanding the evolution of organisms is by studying molecular evolution. With the large number of protein structures identified in the past decades, we have discovered peculiar patterns that nature imprints on protein structural space in the course of evolution. In particular, we have discovered that the universe of protein structures is organized hierarchically into a scale-free network. By understanding the cause of these patterns, we attempt to glance at the very origin of life.
AB - The bottom-up approach to understanding the evolution of organisms is by studying molecular evolution. With the large number of protein structures identified in the past decades, we have discovered peculiar patterns that nature imprints on protein structural space in the course of evolution. In particular, we have discovered that the universe of protein structures is organized hierarchically into a scale-free network. By understanding the cause of these patterns, we attempt to glance at the very origin of life.
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U2 - 10.1073/pnas.202497999
DO - 10.1073/pnas.202497999
M3 - Article
C2 - 12384571
AN - SCOPUS:0037195119
SN - 0027-8424
VL - 99
SP - 14132
EP - 14136
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 22
ER -