Expanding the scope of mast cell disease: Does mast cell-derived TNF play a role in immune-mediated chronic illness and autoimmunity?

Rachel da Silveira Gorman, Iffath Unissa Syed

Research output: Contribution to journalReview articlepeer-review

Abstract

Increasing evidence underscores the vital significance of diverse mast cell mediators in inflammatory illness, yet diagnostic criteria for mast cell activation syndrome still focus predominantly on a solitary mediator, tryptase. Therapeutic interventions, conversely, tend to prioritize histamine, prostaglandins, and leukotrienes. This article, via a review of both experimental and clinical findings, spotlights the mechanisms of action of an important mast cell mediator – tumor necrosis factor (TNF), and elucidates the intricate linkages between mast cell dysfunction, chronic illness, and autoimmunity. After providing an overview of the role of mast cell-derived TNF in inflammatory illnesses and viral infections, we hypothesize the interplay between mast cell-derived TNF and mitochondrial dysfunction, microglial activation, and the hypothalamic-pituitary-adrenal axis and the pathways of action on mast cells of treatments such as high-dose melatonin and low-dose naltrexone.

Original languageEnglish (US)
Pages (from-to)218-225
Number of pages8
JournalRheumatology and Autoimmunity
Volume4
Issue number4
DOIs
StatePublished - Dec 2024

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Immunology and Allergy
  • Rheumatology
  • Immunology

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