TY - JOUR
T1 - Expanding the scope of mast cell disease
T2 - Does mast cell-derived TNF play a role in immune-mediated chronic illness and autoimmunity?
AU - Gorman, Rachel da Silveira
AU - Syed, Iffath Unissa
N1 - Publisher Copyright:
© 2024 The Author(s). Rheumatology & Autoimmunity published by John Wiley & Sons Ltd on behalf of Chinese Medical Association.
PY - 2024/12
Y1 - 2024/12
N2 - Increasing evidence underscores the vital significance of diverse mast cell mediators in inflammatory illness, yet diagnostic criteria for mast cell activation syndrome still focus predominantly on a solitary mediator, tryptase. Therapeutic interventions, conversely, tend to prioritize histamine, prostaglandins, and leukotrienes. This article, via a review of both experimental and clinical findings, spotlights the mechanisms of action of an important mast cell mediator – tumor necrosis factor (TNF), and elucidates the intricate linkages between mast cell dysfunction, chronic illness, and autoimmunity. After providing an overview of the role of mast cell-derived TNF in inflammatory illnesses and viral infections, we hypothesize the interplay between mast cell-derived TNF and mitochondrial dysfunction, microglial activation, and the hypothalamic-pituitary-adrenal axis and the pathways of action on mast cells of treatments such as high-dose melatonin and low-dose naltrexone.
AB - Increasing evidence underscores the vital significance of diverse mast cell mediators in inflammatory illness, yet diagnostic criteria for mast cell activation syndrome still focus predominantly on a solitary mediator, tryptase. Therapeutic interventions, conversely, tend to prioritize histamine, prostaglandins, and leukotrienes. This article, via a review of both experimental and clinical findings, spotlights the mechanisms of action of an important mast cell mediator – tumor necrosis factor (TNF), and elucidates the intricate linkages between mast cell dysfunction, chronic illness, and autoimmunity. After providing an overview of the role of mast cell-derived TNF in inflammatory illnesses and viral infections, we hypothesize the interplay between mast cell-derived TNF and mitochondrial dysfunction, microglial activation, and the hypothalamic-pituitary-adrenal axis and the pathways of action on mast cells of treatments such as high-dose melatonin and low-dose naltrexone.
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U2 - 10.1002/rai2.12151
DO - 10.1002/rai2.12151
M3 - Review article
AN - SCOPUS:85213522344
SN - 2767-1410
VL - 4
SP - 218
EP - 225
JO - Rheumatology and Autoimmunity
JF - Rheumatology and Autoimmunity
IS - 4
ER -