Many types of kinetic studies have been done to investigate the metabolism of retinoids. This chapter reviews the methods used to study vitamin A dynamics in the rat. The approach has been to administer radioactive vitamin A in a physiological form, so that tracer data can be extrapolated to the tracees of interest (retinol and retinyl esters). The chapter applies several kinetic methods to analyze the in vivo data, with the goal of developing a quantitative description of whole-body vitamin A dynamics at different levels of vitamin A status. Such techniques are applicable to studies of vitamin A metabolism in different physiological or nutritional states using rats or other species, as well as to experiments on the effects of alcohol and xenobiotics on vitamin A metabolism and to those on disposition of pharmacologically useful retinoids.
All Science Journal Classification (ASJC) codes
- Molecular Biology