TY - JOUR
T1 - Experimental challenge models for Johne's disease
T2 - A review and proposed international guidelines
AU - Hines, Murray E.
AU - Stabel, Judith R.
AU - Sweeney, Raymond W.
AU - Griffin, Frank
AU - Talaat, Adel M.
AU - Bakker, Douwe
AU - Benedictus, Geart
AU - Davis, William C.
AU - de Lisle, Geoffrey W.
AU - Gardner, Ian A.
AU - Juste, Ramon A.
AU - Kapur, Vivek
AU - Koets, Ad
AU - McNair, Jim
AU - Pruitt, Greg
AU - Whitlock, Robert H.
N1 - Funding Information:
The authors wish to thank Terry Bowersock, David Stewart and Sam Strain for making suggestions and reviewing this manuscript. The authors wish to remember and honor Bob Schroeder, past Johne's Disease Integrated Project (JDIP) associate administrator, for his assistance with the logistics of this project just prior to his untimely passing. This project was funded through JDIP, University of Minnesota (Vivek Kapur, Program Director) and supported by the National Research Initiative of the USDA Cooperative State Research, Education and Extension Service, grant number # 2004-35605-14243.
PY - 2007/6/21
Y1 - 2007/6/21
N2 - An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a "best fit" JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host-pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.
AB - An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a "best fit" JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host-pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.
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U2 - 10.1016/j.vetmic.2007.03.009
DO - 10.1016/j.vetmic.2007.03.009
M3 - Review article
C2 - 17467201
AN - SCOPUS:34249058961
SN - 0378-1135
VL - 122
SP - 197
EP - 222
JO - Veterinary Microbiology
JF - Veterinary Microbiology
IS - 3-4
ER -
