Experimental colitis studied by colonoscopy in the rat: effect of indomethacin

N. S. Mann; L. M. Demers

doi:10.1016/S0016-5107(83)72536-8

Experimental colitis studied by colonoscopy in the rat: effect of indomethacin

N. S. Mann, L. M. Demers

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Diffuse colitis was produced in rats by the intracolonic administation of 10% acetic acid. The course and evolution of this chemical colitis was followed by performing serial fiberoptic colonoscopy and biopsy. The effect of intrarectal indomethacin on the prostaglandin E content of the colonic mucosa and on the severity of colitis as judged by endoscopic and histologic criteria was evaluated. Intrarectal administration of indomethacin was associated with decreased severity of inflammation and decreased prostaglandin E₂ content of the colonic mucosa. This model may be useful in evaluating other potential therapeutic agents.

Original language	English (US)
Pages (from-to)	77-82
Number of pages	6
Journal	Gastrointestinal Endoscopy
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/S0016-5107(83)72536-8
State	Published - 1983

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging
Gastroenterology

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10.1016/S0016-5107(83)72536-8

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title = "Experimental colitis studied by colonoscopy in the rat: effect of indomethacin",

abstract = "Diffuse colitis was produced in rats by the intracolonic administation of 10% acetic acid. The course and evolution of this chemical colitis was followed by performing serial fiberoptic colonoscopy and biopsy. The effect of intrarectal indomethacin on the prostaglandin E content of the colonic mucosa and on the severity of colitis as judged by endoscopic and histologic criteria was evaluated. Intrarectal administration of indomethacin was associated with decreased severity of inflammation and decreased prostaglandin E2 content of the colonic mucosa. This model may be useful in evaluating other potential therapeutic agents.",

author = "Mann, {N. S.} and Demers, {L. M.}",

note = "Funding Information: From Digestive Diseases and Nutrition Section, Veterans Administration Medical Center, University ofLouisville School ofMedicine, Louisville, Kentucky, and Department of Pathology, The Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania. Reprint requests: Dr. N. S. Mann, 800 Zorn Avenue, Lousiville, Kentucky 40202. This work was partly supported by Federal Youth Employment Training Program Grant 538386 and by Veterans Administration Medical Research Service.",

year = "1983",

doi = "10.1016/S0016-5107(83)72536-8",

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T1 - Experimental colitis studied by colonoscopy in the rat

T2 - effect of indomethacin

AU - Mann, N. S.

AU - Demers, L. M.

N1 - Funding Information: From Digestive Diseases and Nutrition Section, Veterans Administration Medical Center, University ofLouisville School ofMedicine, Louisville, Kentucky, and Department of Pathology, The Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania. Reprint requests: Dr. N. S. Mann, 800 Zorn Avenue, Lousiville, Kentucky 40202. This work was partly supported by Federal Youth Employment Training Program Grant 538386 and by Veterans Administration Medical Research Service.

PY - 1983

Y1 - 1983

N2 - Diffuse colitis was produced in rats by the intracolonic administation of 10% acetic acid. The course and evolution of this chemical colitis was followed by performing serial fiberoptic colonoscopy and biopsy. The effect of intrarectal indomethacin on the prostaglandin E content of the colonic mucosa and on the severity of colitis as judged by endoscopic and histologic criteria was evaluated. Intrarectal administration of indomethacin was associated with decreased severity of inflammation and decreased prostaglandin E2 content of the colonic mucosa. This model may be useful in evaluating other potential therapeutic agents.

AB - Diffuse colitis was produced in rats by the intracolonic administation of 10% acetic acid. The course and evolution of this chemical colitis was followed by performing serial fiberoptic colonoscopy and biopsy. The effect of intrarectal indomethacin on the prostaglandin E content of the colonic mucosa and on the severity of colitis as judged by endoscopic and histologic criteria was evaluated. Intrarectal administration of indomethacin was associated with decreased severity of inflammation and decreased prostaglandin E2 content of the colonic mucosa. This model may be useful in evaluating other potential therapeutic agents.

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Experimental colitis studied by colonoscopy in the rat: effect of indomethacin

Abstract

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