Experimental models used to measure direct and indirect ethanol teratogenicity

Ivan A. Shibley; Timothy A. McIntyre; Sam N. Pennington

doi:10.1093/alcalc/34.2.125

Experimental models used to measure direct and indirect ethanol teratogenicity

Ivan A. Shibley, Timothy A. McIntyre, Sam N. Pennington

Division of Science (Berks)

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

The teratogenic effects of ethanol have been widely studied in a variety of experimental models. In humans, ethanol teratogenicity results from both direct and indirect effects. This paper reviews the differences between direct and indirect effects of ethanol on the developing fetus. Experimental paradigms are discussed that attempt to differentiate between direct and indirect effects. For the purpose of this review, direct effects of ethanol are caused by ethanol interacting with the fetal cell. Indirect effects of ethanol teratogenicity are defined as any perturbation of the developing fetus resulting from ethanol exposure but not caused by ethanol's interacting with the fetal cell. Indirect effects of ethanol teratogenicity include: ethanol-induced maternal undernutrition; ethanol-induced placental dysfunction and acetaldehyde teratogenicity.

Original language	English (US)
Pages (from-to)	125-140
Number of pages	16
Journal	Alcohol and Alcoholism
Volume	34
Issue number	2
DOIs	https://doi.org/10.1093/alcalc/34.2.125
State	Published - 1999

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Toxicology
Psychiatry and Mental health

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10.1093/alcalc/34.2.125

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title = "Experimental models used to measure direct and indirect ethanol teratogenicity",

abstract = "The teratogenic effects of ethanol have been widely studied in a variety of experimental models. In humans, ethanol teratogenicity results from both direct and indirect effects. This paper reviews the differences between direct and indirect effects of ethanol on the developing fetus. Experimental paradigms are discussed that attempt to differentiate between direct and indirect effects. For the purpose of this review, direct effects of ethanol are caused by ethanol interacting with the fetal cell. Indirect effects of ethanol teratogenicity are defined as any perturbation of the developing fetus resulting from ethanol exposure but not caused by ethanol's interacting with the fetal cell. Indirect effects of ethanol teratogenicity include: ethanol-induced maternal undernutrition; ethanol-induced placental dysfunction and acetaldehyde teratogenicity.",

author = "Shibley, {Ivan A.} and McIntyre, {Timothy A.} and Pennington, {Sam N.}",

year = "1999",

doi = "10.1093/alcalc/34.2.125",

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AU - Shibley, Ivan A.

AU - McIntyre, Timothy A.

AU - Pennington, Sam N.

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N2 - The teratogenic effects of ethanol have been widely studied in a variety of experimental models. In humans, ethanol teratogenicity results from both direct and indirect effects. This paper reviews the differences between direct and indirect effects of ethanol on the developing fetus. Experimental paradigms are discussed that attempt to differentiate between direct and indirect effects. For the purpose of this review, direct effects of ethanol are caused by ethanol interacting with the fetal cell. Indirect effects of ethanol teratogenicity are defined as any perturbation of the developing fetus resulting from ethanol exposure but not caused by ethanol's interacting with the fetal cell. Indirect effects of ethanol teratogenicity include: ethanol-induced maternal undernutrition; ethanol-induced placental dysfunction and acetaldehyde teratogenicity.

AB - The teratogenic effects of ethanol have been widely studied in a variety of experimental models. In humans, ethanol teratogenicity results from both direct and indirect effects. This paper reviews the differences between direct and indirect effects of ethanol on the developing fetus. Experimental paradigms are discussed that attempt to differentiate between direct and indirect effects. For the purpose of this review, direct effects of ethanol are caused by ethanol interacting with the fetal cell. Indirect effects of ethanol teratogenicity are defined as any perturbation of the developing fetus resulting from ethanol exposure but not caused by ethanol's interacting with the fetal cell. Indirect effects of ethanol teratogenicity include: ethanol-induced maternal undernutrition; ethanol-induced placental dysfunction and acetaldehyde teratogenicity.

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JO - Alcohol and Alcoholism

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Experimental models used to measure direct and indirect ethanol teratogenicity

Abstract

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