TY - JOUR
T1 - Experimental T-2 toxicosis in swine
T2 - I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-pgf1α, thromboxane b2, and acid-base parameters
AU - Lorenzana, Roseanne M.
AU - Beasley, Val R.
AU - Buck, William B.
AU - Ghent, Arthur W.
AU - Lundeen, Gregg R.
AU - Poppenga, Robert H.
N1 - Funding Information:
1Supported by the U.S. Army Medical Research and Development Command, Contract DAMD 17-83-C-2I79. Presented at the FASEB Research Conference, "Diagnosis, Toxicity, and Therapy of Trichothecene Mycotoxicosis," June 1984.
PY - 1985/10
Y1 - 1985/10
N2 - Experimental T-2 Toxicosis in Swine. I. Changes in Cardiac Output, Aortic Mean Pressure, Catecholamines, 6-Keto-PGF1α, Thromboxane B2, and Acid-Base Parameters. LORENZANA, R. M., BEASLEY, V. R., BUCK, W. B., GHENT, A. W., LUNDEEN, G. R., AND POPPENGA, R. H. (1985). Fundam. Appl. Toxicol.. 5,879-892. T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.
AB - Experimental T-2 Toxicosis in Swine. I. Changes in Cardiac Output, Aortic Mean Pressure, Catecholamines, 6-Keto-PGF1α, Thromboxane B2, and Acid-Base Parameters. LORENZANA, R. M., BEASLEY, V. R., BUCK, W. B., GHENT, A. W., LUNDEEN, G. R., AND POPPENGA, R. H. (1985). Fundam. Appl. Toxicol.. 5,879-892. T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.
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U2 - 10.1093/toxsci/5.5.879
DO - 10.1093/toxsci/5.5.879
M3 - Article
C2 - 3840756
AN - SCOPUS:0022341463
SN - 1096-6080
VL - 5
SP - 879
EP - 892
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 5
ER -