TY - JOUR
T1 - Experimental T-2 toxicosis in swine
T2 - II. Effect of intravascular t-2 toxin on serum enzymes and biochemistry, blood coagulation, and hematology
AU - Lorenzana, Roseanne M.
AU - Beasley, Val R.
AU - Buck, William B.
AU - Ghent, Arthur W.
N1 - Funding Information:
T-2 toxin, a potent trichothecene mycotoxin produced primarily by members of the genus Fusariurn, has been reported to cause infertility (Weaver et al, 1978b), hemorrhagic "moldy corn disease" (Bamburg et al, 1969), vomiting, paresis, and death (Weaver et al., 1978a) in swine. In this study, T-2 toxin was given intravascularly to characterize the pathophysiology of the shock syndrome that can be a lethal as well as a sublethal effect in swine (V. R. Beasley, 1983, unpublished data; Lorenzana et al, 1985). T-2 toxin has recently been identified as a component of the "Yellow Rain" chemical warfare agent (Rosen and 1 Supported by the U.S. Army Medical Research and Development Command, Contract DAMD 17-83-C-2179. Presented at the Gordon Research Conference on trichothecene mycotoxins, June 1983.
PY - 1985/10
Y1 - 1985/10
N2 - Experimental T-2 Toxicosis in Swine. II. Effect of Intravascular T-2 Toxin on Serum Enzymes and Biochemistry, Blood Coagulation, and Hematology. LORENZANA, R. M., BEASLEY, V. R., BUCK, W. B., AND GHENT, A. W. (1985). Fundam. Appl. Toxicol.. 5,893-901. T-2 toxin was given as a single intravascular dose at either 0.6 or 4.8 mg/kg to different groups of 50-kg female swine. Blood samples were taken at hourly intervals for determination of concentrations or activities of the following substances in serum or plasma: creatinine, blood urea nitrogen, inorganic phosphorus, total calcium, ultrafilterable calcium, magnesium, sodium, potassium, chloride, total protein, albumin, cholesterol, glucose, alkaline phosphatase, aspartate aminotransferase, and total bilirubin. Coagulation analyses included prothrombin time, partial thromboplastin time, activated coagulation time, and fibrin degradation products. Red blood cell, white blood cell, and platelet counts, hemoglobin concentrations, and hematocrits were determined from whole blood samples. An initial leukocytosis was followed by a leukopenia. The numbers of red cells, the hemoglobin concentration, and the hematocrit were increased. Nucleated red blood cells were seen in the blood smears. The serum concentration of bound calcium decreased, while phosphorus, magnesium, and potassium increased. Clinical screening tests detected no evidence of a coagulopathy in swine given T-2 toxin intravascularly.
AB - Experimental T-2 Toxicosis in Swine. II. Effect of Intravascular T-2 Toxin on Serum Enzymes and Biochemistry, Blood Coagulation, and Hematology. LORENZANA, R. M., BEASLEY, V. R., BUCK, W. B., AND GHENT, A. W. (1985). Fundam. Appl. Toxicol.. 5,893-901. T-2 toxin was given as a single intravascular dose at either 0.6 or 4.8 mg/kg to different groups of 50-kg female swine. Blood samples were taken at hourly intervals for determination of concentrations or activities of the following substances in serum or plasma: creatinine, blood urea nitrogen, inorganic phosphorus, total calcium, ultrafilterable calcium, magnesium, sodium, potassium, chloride, total protein, albumin, cholesterol, glucose, alkaline phosphatase, aspartate aminotransferase, and total bilirubin. Coagulation analyses included prothrombin time, partial thromboplastin time, activated coagulation time, and fibrin degradation products. Red blood cell, white blood cell, and platelet counts, hemoglobin concentrations, and hematocrits were determined from whole blood samples. An initial leukocytosis was followed by a leukopenia. The numbers of red cells, the hemoglobin concentration, and the hematocrit were increased. Nucleated red blood cells were seen in the blood smears. The serum concentration of bound calcium decreased, while phosphorus, magnesium, and potassium increased. Clinical screening tests detected no evidence of a coagulopathy in swine given T-2 toxin intravascularly.
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U2 - 10.1093/toxsci/5.5.893
DO - 10.1093/toxsci/5.5.893
M3 - Article
C2 - 4065462
AN - SCOPUS:77957187559
SN - 1096-6080
VL - 5
SP - 893
EP - 901
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 5
ER -