Abstract
A strategy for a total synthesis of the marine alkaloid perophoramidine has been investigated. Key steps which have been tested include a tandem intramolecular Heck/carbonylation reaction and a stereoselective allylation of a pentacyclic δ-lactam to produce the C-4/20 vicinal quaternary centers having the requisite relative configuration of the metabolite.
Original language | English (US) |
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Pages (from-to) | 6712-6719 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 65 |
Issue number | 33 |
DOIs | |
State | Published - Aug 15 2009 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry