Exploring bubble oscillation and mass transfer enhancement in acoustic-assisted liquid-liquid extraction with a microfluidic device

Yuliang Xie; Chandraprakash Chindam; Nitesh Nama; Shikuan Yang; Mengqian Lu; Yanhui Zhao; John D. Mai; Francesco Costanzo; Tony Jun Huang

doi:10.1038/srep12572

Exploring bubble oscillation and mass transfer enhancement in acoustic-assisted liquid-liquid extraction with a microfluidic device

Yuliang Xie, Chandraprakash Chindam, Nitesh Nama, Shikuan Yang, Mengqian Lu, Yanhui Zhao, John D. Mai, Francesco Costanzo, Tony Jun Huang

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

We investigated bubble oscillation and its induced enhancement of mass transfer in a liquid-liquid extraction process with an acoustically-driven, bubble-based microfluidic device. The oscillation of individually trapped bubbles, of known sizes, in microchannels was studied at both a fixed frequency, and over a range of frequencies. Resonant frequencies were analytically identified and were found to be in agreement with the experimental observations. The acoustic streaming induced by the bubble oscillation was identified as the cause of this enhanced extraction. Experiments extracting Rhodanmine B from an aqueous phase (DI water) to an organic phase (1-octanol) were performed to determine the relationship between extraction efficiency and applied acoustic power. The enhanced efficiency in mass transport via these acoustic-energy-assisted processes was confirmed by comparisons against a pure diffusion-based process.

Original language	English (US)
Article number	12572
Journal	Scientific reports
Volume	5
DOIs	https://doi.org/10.1038/srep12572
State	Published - Jul 30 2015

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title = "Exploring bubble oscillation and mass transfer enhancement in acoustic-assisted liquid-liquid extraction with a microfluidic device",

abstract = "We investigated bubble oscillation and its induced enhancement of mass transfer in a liquid-liquid extraction process with an acoustically-driven, bubble-based microfluidic device. The oscillation of individually trapped bubbles, of known sizes, in microchannels was studied at both a fixed frequency, and over a range of frequencies. Resonant frequencies were analytically identified and were found to be in agreement with the experimental observations. The acoustic streaming induced by the bubble oscillation was identified as the cause of this enhanced extraction. Experiments extracting Rhodanmine B from an aqueous phase (DI water) to an organic phase (1-octanol) were performed to determine the relationship between extraction efficiency and applied acoustic power. The enhanced efficiency in mass transport via these acoustic-energy-assisted processes was confirmed by comparisons against a pure diffusion-based process.",

author = "Yuliang Xie and Chandraprakash Chindam and Nitesh Nama and Shikuan Yang and Mengqian Lu and Yanhui Zhao and Mai, {John D.} and Francesco Costanzo and Huang, {Tony Jun}",

note = "Funding Information: This research was supported by National Institutes of Health (1 R01 GM112048-01A1 and 1R33EB019785-01); an American Asthma Foundation (AAF) scholar award; the National Science Foundation (CBET-1438126 and IIP-1346440), and the Penn State Center for Nanoscale Science (MRSEC) under grant DMR-0820404. Components of this work were conducted at the Penn State node of the NSF-funded National Nanotechnology Infrastructure Network.",

year = "2015",

month = jul,

day = "30",

doi = "10.1038/srep12572",

language = "English (US)",

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journal = "Scientific reports",

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T1 - Exploring bubble oscillation and mass transfer enhancement in acoustic-assisted liquid-liquid extraction with a microfluidic device

AU - Xie, Yuliang

AU - Chindam, Chandraprakash

AU - Nama, Nitesh

AU - Yang, Shikuan

AU - Lu, Mengqian

AU - Zhao, Yanhui

AU - Mai, John D.

AU - Costanzo, Francesco

AU - Huang, Tony Jun

N1 - Funding Information: This research was supported by National Institutes of Health (1 R01 GM112048-01A1 and 1R33EB019785-01); an American Asthma Foundation (AAF) scholar award; the National Science Foundation (CBET-1438126 and IIP-1346440), and the Penn State Center for Nanoscale Science (MRSEC) under grant DMR-0820404. Components of this work were conducted at the Penn State node of the NSF-funded National Nanotechnology Infrastructure Network.

PY - 2015/7/30

Y1 - 2015/7/30

N2 - We investigated bubble oscillation and its induced enhancement of mass transfer in a liquid-liquid extraction process with an acoustically-driven, bubble-based microfluidic device. The oscillation of individually trapped bubbles, of known sizes, in microchannels was studied at both a fixed frequency, and over a range of frequencies. Resonant frequencies were analytically identified and were found to be in agreement with the experimental observations. The acoustic streaming induced by the bubble oscillation was identified as the cause of this enhanced extraction. Experiments extracting Rhodanmine B from an aqueous phase (DI water) to an organic phase (1-octanol) were performed to determine the relationship between extraction efficiency and applied acoustic power. The enhanced efficiency in mass transport via these acoustic-energy-assisted processes was confirmed by comparisons against a pure diffusion-based process.

AB - We investigated bubble oscillation and its induced enhancement of mass transfer in a liquid-liquid extraction process with an acoustically-driven, bubble-based microfluidic device. The oscillation of individually trapped bubbles, of known sizes, in microchannels was studied at both a fixed frequency, and over a range of frequencies. Resonant frequencies were analytically identified and were found to be in agreement with the experimental observations. The acoustic streaming induced by the bubble oscillation was identified as the cause of this enhanced extraction. Experiments extracting Rhodanmine B from an aqueous phase (DI water) to an organic phase (1-octanol) were performed to determine the relationship between extraction efficiency and applied acoustic power. The enhanced efficiency in mass transport via these acoustic-energy-assisted processes was confirmed by comparisons against a pure diffusion-based process.

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Exploring bubble oscillation and mass transfer enhancement in acoustic-assisted liquid-liquid extraction with a microfluidic device

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