Exposure-safety relationship for acyclovir in the treatment of neonatal herpes simplex virus disease

Keyphrases

• Acyclovir 100%
• Herpes Simplex Virus 100%
• Virus Diseases 100%
• Neonatal Herpes 100%
• Adverse Events 72%
• High Dose 27%
• Maximum Tolerated Dose 27%
• Odds Ratio 18%
• Clinical Adverse Events 18%
• Age Groups 9%
• Non-associated 9%
• Gestational Age 9%
• Medical Records 9%
• Area under the Curve 9%
• Rash 9%
• Children's Hospital 9%
• Demographic Information 9%
• Hypokalemia 9%
• Daily Dose 9%
• Postnatal Age 9%
• Maximum Permissible Concentration 9%
• Cmax 9%
• Blood Urea Nitrogen 9%
• Pharmacokinetic Model 9%
• Severe Adverse Events 9%
• Thrombocytosis 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Virus Infection 100%
• Adverse Event 100%
• Herpes Simplex Virus 100%
• Aciclovir 100%
• Rash 9%
• Ureaplasma 9%
• Hypokalemia 9%
• Thrombocytosis 9%

Immunology and Microbiology

• Herpes Simplex Virus 100%
• Drug Megadose 60%
• Maximum Permissible Dose 60%
• Pharmacokinetics 20%
• Urea Nitrogen Blood Level 20%
• Medical Record 20%
• Maximum Concentration 20%