Expression and function of tetraspanins and their interacting partners in B cells

Fagui Zou, Xu Wang, Xinxin Han, Gerson Rothschild, Song Guo Zheng, Uttiya Basu, Jianbo Sun

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Tetraspanins are transmembrane proteins that modulate multiple diverse biological processes, including signal transduction, cell-cell communication, immunoregulation, tumorigenesis, cell adhesion, migration, and growth and differentiation. Here, we provide a systematic review of the involvement of tetraspanins and their partners in the regulation and function of B cells, including mechanisms associated with antigen presentation, antibody production, cytokine secretion, co-stimulator expression, and immunosuppression. Finally, we direct our focus to the signaling mechanisms, evolutionary conservation aspects, expression, and potential therapeutic strategies that could be based on tetraspanins and their interacting partners.

Original languageEnglish (US)
Article number1606
JournalFrontiers in immunology
Issue numberJUL
StatePublished - Jul 18 2018

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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