TY - JOUR
T1 - Expression and function of tetraspanins and their interacting partners in B cells
AU - Zou, Fagui
AU - Wang, Xu
AU - Han, Xinxin
AU - Rothschild, Gerson
AU - Zheng, Song Guo
AU - Basu, Uttiya
AU - Sun, Jianbo
N1 - Funding Information:
This research is supported by the Program for Guangdong Introducing Innovative and Entrepreneurial Teams (2016ZT06S252) to JS and SZ; and by NIH/NIAID grants (R01AI099195 and R01AI134988), Leukemia and Lymphoma Society of America award, and Pershing Square Sohn Cancer Research Alliance award to UB.
Publisher Copyright:
© 2018 Zou, Wang, Han, Rothschild, Zheng, Basu and Sun.
PY - 2018/7/18
Y1 - 2018/7/18
N2 - Tetraspanins are transmembrane proteins that modulate multiple diverse biological processes, including signal transduction, cell-cell communication, immunoregulation, tumorigenesis, cell adhesion, migration, and growth and differentiation. Here, we provide a systematic review of the involvement of tetraspanins and their partners in the regulation and function of B cells, including mechanisms associated with antigen presentation, antibody production, cytokine secretion, co-stimulator expression, and immunosuppression. Finally, we direct our focus to the signaling mechanisms, evolutionary conservation aspects, expression, and potential therapeutic strategies that could be based on tetraspanins and their interacting partners.
AB - Tetraspanins are transmembrane proteins that modulate multiple diverse biological processes, including signal transduction, cell-cell communication, immunoregulation, tumorigenesis, cell adhesion, migration, and growth and differentiation. Here, we provide a systematic review of the involvement of tetraspanins and their partners in the regulation and function of B cells, including mechanisms associated with antigen presentation, antibody production, cytokine secretion, co-stimulator expression, and immunosuppression. Finally, we direct our focus to the signaling mechanisms, evolutionary conservation aspects, expression, and potential therapeutic strategies that could be based on tetraspanins and their interacting partners.
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U2 - 10.3389/fimmu.2018.01606
DO - 10.3389/fimmu.2018.01606
M3 - Review article
C2 - 30072987
AN - SCOPUS:85050104599
SN - 1664-3224
VL - 9
JO - Frontiers in immunology
JF - Frontiers in immunology
IS - JUL
M1 - 1606
ER -