Expression and function of trk-C in favourable human neuroblastomas

D. J. Yamashiro; X. G. Liu; C. P. Lee; A. Nakagawara; N. Ikegaki; L. M. McGregor; S. B. Baylin; G. M. Brodeur

doi:10.1016/S0959-8049(97)00309-2

Expression and function of trk-C in favourable human neuroblastomas

D. J. Yamashiro, X. G. Liu, C. P. Lee, A. Nakagawara, N. Ikegaki, L. M. McGregor, S. B. Baylin, G. M. Brodeur

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Abstract

Human neuroblastomas express the neurotrophin receptors trk-A and trk- B. Favourable outcome is associated with expression of trk-A, while unfavourable, MYCN amplified tumours express trk-B. In this study we examined the expression of trk-C in primary neuroblastoma tumour-derived cell lines. We found by Northern blot analysis that trk-C mRNA is expressed in 14 of 55 (25%) primary tumours. Trk-C was expressed in significantly more lower stage tumours (stage 1, 2, 4S) than higher stage tumours (stage 3, 4, P < 0.04). The expression of trk-C was correlated positively with survival and negatively correlated with MYCN amplification. We also studied the function of trk-C in transfected cell lines and found that NT-3 promotes both cell survival and differentiation. Our results suggest that trk-C is involved in the biology of favourable neuroblastomas.

Original language	English (US)
Pages (from-to)	2054-2057
Number of pages	4
Journal	European Journal of Cancer
Volume	33
Issue number	12
DOIs	https://doi.org/10.1016/S0959-8049(97)00309-2
State	Published - Oct 1997

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Oncology
Cancer Research

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@article{9f725de117e14d2587135674e08b7db3,

title = "Expression and function of trk-C in favourable human neuroblastomas",

abstract = "Human neuroblastomas express the neurotrophin receptors trk-A and trk- B. Favourable outcome is associated with expression of trk-A, while unfavourable, MYCN amplified tumours express trk-B. In this study we examined the expression of trk-C in primary neuroblastoma tumour-derived cell lines. We found by Northern blot analysis that trk-C mRNA is expressed in 14 of 55 (25%) primary tumours. Trk-C was expressed in significantly more lower stage tumours (stage 1, 2, 4S) than higher stage tumours (stage 3, 4, P < 0.04). The expression of trk-C was correlated positively with survival and negatively correlated with MYCN amplification. We also studied the function of trk-C in transfected cell lines and found that NT-3 promotes both cell survival and differentiation. Our results suggest that trk-C is involved in the biology of favourable neuroblastomas.",

author = "Yamashiro, {D. J.} and Liu, {X. G.} and Lee, {C. P.} and A. Nakagawara and N. Ikegaki and McGregor, {L. M.} and Baylin, {S. B.} and Brodeur, {G. M.}",

note = "Funding Information: This work was supported in part by grants from Ronald McDonald Children{\textquoteright}s Charities (G.M.B.) and by NIH training grant CA 09615 (D.J.Y.).",

year = "1997",

month = oct,

doi = "10.1016/S0959-8049(97)00309-2",

language = "English (US)",

volume = "33",

pages = "2054--2057",

journal = "European Journal of Cancer",

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T1 - Expression and function of trk-C in favourable human neuroblastomas

AU - Yamashiro, D. J.

AU - Liu, X. G.

AU - Lee, C. P.

AU - Nakagawara, A.

AU - Ikegaki, N.

AU - McGregor, L. M.

AU - Baylin, S. B.

AU - Brodeur, G. M.

N1 - Funding Information: This work was supported in part by grants from Ronald McDonald Children’s Charities (G.M.B.) and by NIH training grant CA 09615 (D.J.Y.).

PY - 1997/10

Y1 - 1997/10

N2 - Human neuroblastomas express the neurotrophin receptors trk-A and trk- B. Favourable outcome is associated with expression of trk-A, while unfavourable, MYCN amplified tumours express trk-B. In this study we examined the expression of trk-C in primary neuroblastoma tumour-derived cell lines. We found by Northern blot analysis that trk-C mRNA is expressed in 14 of 55 (25%) primary tumours. Trk-C was expressed in significantly more lower stage tumours (stage 1, 2, 4S) than higher stage tumours (stage 3, 4, P < 0.04). The expression of trk-C was correlated positively with survival and negatively correlated with MYCN amplification. We also studied the function of trk-C in transfected cell lines and found that NT-3 promotes both cell survival and differentiation. Our results suggest that trk-C is involved in the biology of favourable neuroblastomas.

AB - Human neuroblastomas express the neurotrophin receptors trk-A and trk- B. Favourable outcome is associated with expression of trk-A, while unfavourable, MYCN amplified tumours express trk-B. In this study we examined the expression of trk-C in primary neuroblastoma tumour-derived cell lines. We found by Northern blot analysis that trk-C mRNA is expressed in 14 of 55 (25%) primary tumours. Trk-C was expressed in significantly more lower stage tumours (stage 1, 2, 4S) than higher stage tumours (stage 3, 4, P < 0.04). The expression of trk-C was correlated positively with survival and negatively correlated with MYCN amplification. We also studied the function of trk-C in transfected cell lines and found that NT-3 promotes both cell survival and differentiation. Our results suggest that trk-C is involved in the biology of favourable neuroblastomas.

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JO - European Journal of Cancer

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IS - 12

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Expression and function of trk-C in favourable human neuroblastomas

Abstract

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